Multimedia learning proposes Essay

Multimedia learning proposes ways of going beyond the pure verbal messages which have been used in lectures and printed lessons for hundreds of years. Multimedia learning as Thomas Edison predicted has proved to be an effective method of teaching, has revolutionized our educational system and has supplanted the use of textbooks. Multimedia presentations are known to help learners. The newly developed multimedia technologies which incorporate simultaneous presentations of narration, images and text make the possibilities for instruction vast. Yet how should educators use these technologies to ensure that there is optimal learning? The answer is that the multimedia messages should be designed in the best way using the eight principles for multimedia design as a guideline. Background to the multimedia principles: Mayer is known for his research in the field of cognitive theory. According to Mayer, a multimedia instructional message is a presentation which involves words (such as spoken or written text) and pictures (such as animation, video, illustrations, and photographs) in which the goal is to promote learning. Mayer links cognitive learning theory to multimedia design issues, validating three theory-based assumptions about how people learn from words and pictures: the (1) dual channel assumption which is based upon the theory that pictures are seen by eyes and are processed as pictorial representations in the visual-pictorial channel. Spoken words on the other hand enter through ears and are processed in the other channel of human cognition, the auditory-verbal channel. (2) Limited capacity assumption is demonstrated by auditory- verbal overload. Because each channel in the human cognitive system has a limited capacity for holding and manipulating knowledge, presenting too many visuals and a lot of sounds at the same time causes the auditory-visual channel to become overloaded. And the (3) Active processing assumption implies that optimal learning occurs when learners engage in active processing within the channels which include relevant words and pictures organized into coherent pictorial and verbal models and integrated with each other and other knowledge. The discovery of the eight principles of multimedia design was a result of Mayer’s research. Each principle was based on the cognitive theory and was supported by the finding of the research. The multimedia principles discussed with good and bad practice examples: These eight principles are explained as follows in more detail, along with their applications. Multimedia Principle: This principle states that carefully and selectively chosen words and pictures enhance a learner’s understanding of an explanation better than words alone. Mayer tells us that deeper understanding occurs because students mentally connect pictorial and verbal representations of the explanation. A study was conducted in which students viewed a narrated animation about pumps or brakes or simply listened to a narration; the students who viewed the narrated animation scored substantially higher. There are numerous examples of the multimedia principle. Desktop publishing programs and the illustrative capabilities of Microsoft Word and PowerPoint adding pictures to a multimedia presentation has become relatively easy. A good practice example would be to use an animation of how an earthquake occurs to support the textual and/or verbal description: â€Å"when the frictional stress of gliding plate boundaries goes beyond a certain value and causes a failure at a fault line, which results in a violent dislocation of the Earth’s crust. At this point, elastic strain energy is released causing elastic waves to be radiated, leading to an earthquake. † The goal of this principle is best achieved when graphics used are meaningful and illustrative in juxtaposition with text. Images which convey meaning, not simply multitudes of clip art images with no instructional purpose. It would be bad practice heaps of pictures which show destructions caused by earthquakes are used when explaining how earthquakes occur. It would actually be a hindrance in the process of learning as it would take focus off the topic and instead bring the costs of the earthquake into discussion. A good use of this principle would be when pictures and animations are used for presenting instructional content where there are used as lesson interfaces and not for any decorative purpose. Contiguity Principle: The contiguity principle examines how words and pictures should be coordinated in multimedia presentations. This principle states that there is more effective learning when the narration and animation are presented simultaneously rather than successively. Also, words and associative pictures should be close each other and presented at the same time so that when the narration or words describes a particular process or action, the animation or picture shows it at the same time. A good practice example of the contiguity principle would be showing a car assembly procedure where narration and video are presented simultaneously. Students would learn better when the two things are coordinated than otherwise. It would be bad practice if the entire textual description or narration of the car assembly procedure which has 23 stages is presented first, prior to the animation or when the animation is played prior to the verbal description. A good idea is to display the narration and animation in close time proximity so that when words describe the action, the visual depicts the same action at the same time. This will make it more likely for the learner to build mental connections linking the verbal and visual representations. Modality Principle: This principle states that students learn more deeply and effectively when words are presented as narration rather than on-screen text. Using animation and text is a method most people use when designing PowerPoint presentations. According to Mayer when both pictures and words are used are displayed in multimedia, only the visual channel is utilized and it easily becomes overloaded. A good idea therefore is to use both processing channels; the visual/pictorial channel and the auditory/verbal channel. When the narration presented is auditory, it is processed by the auditory channel allowing the visual channel the resources to process the graphical content without it becoming overloaded. A good practice example of this principle would be to present an animation of how a bicycle tire pump works together with the narration of the explanation. Presenting some information in visual mode and some in auditory mode will expand working memory capacity and reduce excessive cognitive load. It would not be a good idea to play the narration after or before the animation. Redundancy Principle: This principle states that students learn far better from multimedia presentations consisting of animation and narration than from animation, narration, and text. The redundancy principle rejects the idea of presenting duplicate instructions in different forms. Unless it is necessary, presenting the same information both in narration and on-screen text hinders the process of learning rather than facilitating it. Some people think presenting the same information in multiple forms is safe and at best advantageous. However we must understand the architecture of human cognition. When dealing with new and technical instruction, working memory is very limited and presenting the same information in narration and on-screen text will mean that not all information will be processed. A good practice of this principle would be when a lecturer uses presentations to deliver his lectures. He can narrate the instructions while his presentations present animation and pictures. It would not be good practice if the lecturer has text heavy-slides and yet continues to try to maintain the attention of the audience. This redundancy causes the learners or audience to become wrapped up in either the verbal presentation or the textual material and miss the other. Even worse the learner may decide to not pay attention at all when he is being bombarded with so much information. Coherence Principle: This principle states that students learn better from multimedia presentations when irrelevant material is excluded rather than integrated. Irrelevant words and pictures, interesting but irrelevant sounds and unnecessary words huts the student’s learning process. Learners throughout the multimedia presentation try to make sense of the material by building a coherent mental representation and any irrelevant information that comes out of nowhere is likely to disturb the process. A good practice example of this principle would be that when discussing the issue of widespread public display of affection and whether there should be laws imposed against it. It would be a good idea to stick to the topic and present points for or against the argument and the reach a conclusion. If however a person is tempted to spice up the presentation, it would be bad practice. Including dramatic stories of politicians engaged in the art of public affection and video clips where couples are seen showing affection in public would be highly entertaining but off topic and the audience might get upset if they do not make out anything from the four hour long presentation. It would also not be a good idea to include any other non instructional material such as unrelated clip arts, background music, sound clips or detailed textual descriptions. Personalization Principle: The personalization principle states that students learn better when words are presented in a conversational style than in a formal or expository style. Students or audience responds better when a more personalized tone is used in narration. A good example of this principle is when explaining how a human respiratory system works, there is a use of ‘your’ instead of ‘the’. For example instead of saying † During inhaling the diaphragm move down creating more space for the lungs† we say † When you inhale, your diaphragm moves down creating more space for your lungs†. Also when addressing community issues using multimedia presentations it is always a good idea to use ‘your community’ rather than ‘the community’. It will help the learners see that it is his community that has issue and not some other community and will provoke him to take action or become a responsible member of the community. Segmenting principle: This principle states that lessons should be divided into manageable segments. When an unfamiliar learner is introduced to a continuous presentation with a lot of inter related concepts which are complex it is easy for the cognitive system to become overloaded. A good practice of this principle would be when a lecture breaks down complex geometry problems into segments rather than present them as a single solution. This helps learners learn at their own pace. Pre-training principle: This principle suggests that people learn better from multimedia presentations when they are familiar with the names and idea of the core concepts. There is a better transfer of knowledge when the audience is trained on the components the presentation would use preceding a narrated animation. A good practice of this example is when explaining the phenomenon of global warming to children, it would work better when terminologies such as green house gases are explained and smaller concepts are built before proceeding to the presentation. This will help the children integrate their built in concepts into understanding the main problem of global warming. It is not good practice to start with the subject before providing the learners with an appropriate start up knowledge neither would it be a good idea to stop in the middle of the lecture to explain some terminology or a hidden concept. Conclusion: Multimedia enhances learning but for learning to be optimal, there should be effective use of animation, narration and on-screen test in multimedia presentations. Techniques to increase working memory by reducing cognitive load have been proposed by many theorists. These techniques improve instructional design, learning efficiency, and effectiveness. Richard E. Mayer and his Cognitive Theory of Multimedia Learning has highlighted well-established principles of multimedia learning which the research continues to support, including (a) the multimedia principle, (b) the contiguity principle, (d) the modality principle, (e) the redundancy principle, and (f) the coherence principle and (e) the personalization principle. These principles aid users to design effective multimedia presentations. References Clark, R. C. & Mayer, R. E. (2003). e- Learning and the science of instruction: Proven guidelines for consumers and designers of multimedia learning. San Francisco: Jossey-Bass/Pfeiffer.

Business Plan – Convenience Store

Business Plan Buster’s A cozy Store that designed for your needs [pic] Business Plan by Lydia Chan CONTENTS[pic] 1. Executive Summary Buster’s is a convenience store specialized in servicing daily needs of occupants of the office building where it is located. It offers variety of products to satisfy customers’ daily needs including snacks, pre-wrapped sandwiches, bottle/canned beverages, stationery, greeting cards, newspapers, paperback books and small gift items. The first Buster’s Store was set up in 2007, a 1,000 square feet store located in the lobby of Empire Centre in Kennedy commercial district. This store is solely owned and managed by Lydia Chan. With fully focused and correct business strategy, Buster’s been able to get break-even in the eleventh month, and reaches to an annual revenue to US$300,000 last year. It has successfully built up an image of a convenience store that is friendly and customized to the occupants of the Empire Centre and the neighborhood buildings. With the proven success of the first Buster’s Store, Lydia is fully confident to expand the business by opening a second store with identical business strategy. The key to success is to find another perfect location. The golden opportunity is now appearing, there is a new office building, Sky Tower, will be opened by end of this year. Sky Tower is just two blocks away from Empire Centre. Besides the advantage of easy management derived from the close by location of the two stores, to make this location perfect for Buster’s is that Sky Tower is an A grade eighty-storey office building which create huge number of potential customers for Buster’s. 1. Mission The Mission of Buster’s is to provide friendly service and good quality of products to occupants of the buildings. Good mix of variety product items are perfectly meet customers’ needs in their daily work lives. 2. Objectives 1. To make Buster’s the preferred convenience store for the occupants of the building where it is situated and the neighborhood. 2. To break-even by the end of the first year. 3. To achieve a net profit of 5% by year three. 3. Keys to Success 1. Establish an image that Buster’s is â€Å"their† convenience store for the customers. 2. To turn over inventory an average of 15 – 20 times per year. 3. To provide friendly service and premium quality products. 2. Company Summary The first Buster’s store is owned and operated by the founder, Lydia Chan, in Sole Proprietorship. The concept of this new venture is a convenience store that specially services occupants of the office building where it is situated. The first store was set up in 2007 located in Empire Centre in Jordan district. It is a 1,000 square feet store in the lobby with 2 full time employees. In 2009, annual revenue of this store is US$300,000. With the earned capital and experiences from the first store, Lydia believes it is the mature time to expand her business by establishing a second store. In order to strengthen the financial and professional background, the second store will be in partnership set up. 1. Ownership The new Buster’s store is privately owned corporation in partnership basis. Lydia Chan owns 75% of the second store. She will work full-time in the store in the first year to ensure smooth day to day operation. In the second year and onwards she will be half day in the first store and half day in the second one. Carmen Chan owns 25% of the second store. Carmen is the elder sister of Lydia, she is a chartered accountant in Hong Kong Bank. She will provide financial advice and assistant for Buster’s. 2. Employees Base on the experience of the first store, we anticipate two employees are sufficient for the daily operational need. There are two full-time shop assistants in the first Buster’s store, Christine and Mina. Christine, high school graduated, joined Buster’s since it was launched in 2007. Her experiences in nurturing infancy Buster’s and daily operation are valuable to the second store. She will be promoted as shop supervisor and transfer to the new store. Christine will be responsible to coach and mentor the other new hired shop assistant, service customers, keep tract inventory/replenishment and report customers’ comments/complaints to Lydia for ensuring corrective action be taken. We will hire another shop assistant to work together with Christine. Criteria are High school graduate with 1-2 years retailing sales experience. 3. Financials 1. Start-up Finance Summary Anticipated start-up cost of the new store is US$200,000. The main cost of start-up will be inventory. It is estimated that the initial inventory purchase will be $100,000. In addition, $30,000 will have to be spent on fixtures and fittings for the store. Since it is a brand new building, there will be no maintenance needed before move-in. Funding will be come from the combination of the two owners from their own savings. Lydia Chan (75% ownership) – contributes US$150,000 Carmen Chan (25% ownership) – contribute US$50,000 2. Start-up Cost Summary This table shows a summary of start-up cost and expenses [pic] 3. 3 Anticipated Revenue and Operating Cost for the First Year pic] 3. 4 Pro-forma cash flow projection for the first year of operation [pic] 5. Break even Analysis The following chart and table show the break-even analysis for Buster’s [pic] [pic] 3. 6 Anticipated return on investment in the first three Years The following table provides the anticipated return on investment from the perspective of three years into the revenue [pic] 4. Marketing /Sales 1. Sum mary of Marketing and Sales Strategy Buster’s new store will be situated in the lobby of Sky Tower, a new office building in a concentrated commercial area, Kennedy District. Busters’ key customers are occupants of Sky Tower. According to the information from the Building Management office, 80% of the total vacant units were leased out and under interior fixtures and fittings stage. These companies will be moving in within two to three months which will secure customers flow when Buster’s is launched. 4. 2 Market Segmentation Occupants of the building are owners and employees of medium to sizable international corporations. They can be divided into 3 market segments : A) Aged 25 – 39 Male They require speedy service, just pick and pay. Half of them are wealthy Yuppies in managerial level, they do not mind to pay a little higher for the convenience and good quality. They are busy in work and social life, our fresh pre-wrapped sandwiches, popular bottled beverages and high end imported snacks will suit their needs. B) Aged 22 – 35 Female Same phenomenon as other prosperous cities, all ladies are keen to slim down their bodies and are cautious in selecting food. It is more obvious for this age group of ladies. They always search for healthy food and snacks. On every category of food, Buster’s will have a special corner for healthy food with notes on shelves for their easy perusal. Healthy food including vegetarian brown bread pre-wrapped sandwiches, low calories snacks, herbal tea and fruit juice types of bottled beverages and etc. These ladies may be secretaries or work in the administrative departments who are responsible to purchase stationeries for the offices. They will naturally select Buster’s for convenience while they are purchasing their own personal needs. This is a critical customers group for Buster’s. C) Miscellaneous This includes the middle-aged group, outsiders/visitors and etc that they have varied or unpredictable buying pattern. Continuous analysis of this group is required in a quarterly basis when Buster’s store is launched to ensure our service and products cover their needs. 3. Product Strategy Buster’s emphases are on friendly service and good quality of products that fit the requirements of people in their workplace. We do not just follow what selling in super markets or franchised convenience stores. We focus on customization. The following listed are the key categories for Buster’s. A) Pre-wrapped sandwiches : Homemade sandwiches with 4 different choices of fillings : egg and ham, beef, chicken breast and assorted vegetables. These are basic pre-wrapped sandwiches. In addition, we also provide small individual packed fillings such as chess, tomato, cucumber and eggs as supplements, so customers can design and make their own sandwiches in their offices. This will satisfied customers who are looking for variety of choices but without burdening our inventory. B) Bottled/Canned beverages The most popular bottled/canned beverages are available in Buster’s which including soft drinks, coffee, tea and milk. We also provide healthy drinks such as herbal tea, flower flavored tea, juice, Soya bean milk, flavored mineral water, and etc. C) Snacks Popular branded snacks of chips, chocolates, candies and gums are must items in the shelves. To take care of the needs for customers who are pursuing for healthy life, special selection of snacks such as sun-dried fruits, organic food, low calories/calcium crackers, sugar free candies/gums are also available in our â€Å"Healthy Corner†. D) Stationery and Greeting Cards To take care of the sudden or urgent needs of the office people, we will provide certain basic items of stationery and greeting cards but to cautiously control this category of goods occupying not exceed 10% of total display/shelf space. E) Gifts Small gifts can also be found in Buster’s. Regular items are gift sets of premium chocolates and tea bags which are appropriate round the year and for all occasions. Buster will display specialty gifts in front desk for festivals like New Year, Valentines’ day, Easter, Halloween, Christmas and etc. The specialty gift sets to serve both purposes of stimulating sales and decorating the store to lift up spirits. F) Newspapers & Magazine The top five Best selling newspapers are available in Buster’s. 6 – 8 different categories of magazines about fashions, accessories, entertainment, computers, automobiles to cover varied customers’ desires. 4. Pricing Strategy As mentioned in the product strategy section, most of the categories are not common products as other convenience stores because Buster’s emphasis is on premium quality food and drinks. She is comparatively not facing harsh price comparison as other franchise convenience stores for different target customers. Buster’s customers, occupants of Sky Tower, mainly are yuppies and office ladies, who are willing to pay a little more for convenience and better quality. Therefore, Buster’s price ranges for key products are : ? Pre-wrapped sandwiches US$4. 0 – US$5. 5. ? Premium quality and healthy snacks US$2. 5 – US$7. 0 ? Canned/bottled beverages US1. 2 – US$3. 0 ? Common products that are also available in other convenience stores : 5 to 10 percent higher than them. Target is to reach gross margin (sales deduct cost of goods) at 37. 5 – 38% 4. 5 Promotion Strategy Buster’s customer base is concentrated and close-by, they will pass by the store everyday when they go to work. Location is our best promotion tool. Occupants of Sky Tower will know the existence of Buster, so our focus of promotion is to attract them to stop by Buster’s and to experience the difference with other ordinary convenience stores. They will be impressed by our friendly service, wide ranges and unique food and beverages. Word-of-mouth will be our largest promoter. A) Flyers Flyers, an effective and inexpensive way to notify people in Sky Tower and neighborhood buildings that their store â€Å"Buster’s† is opening soon. Flyers will be passed around at the building entrance a week before grand opening. On face side of flyers is an attractive designer sketch of the Buster’s store (sketch is used to be more attractive than photo or words), and on the reverse side is a list of product items that will be available in Buster’s. Distribution of flyers will be continuous after Buster’s is opened. Distribution spots will also be increased to cover the neighborhood buildings. B) Buster’s Card For initial purchase exceeding US$10, a Buster’s Card will be provided with a Buster’s logo stamp on it. Each $10 purchase onwards will earn a stamp. When accumulated to 5 stamps, a free gift will be given. This is effective to stimulate customers to buy more, or to request their colleagues to consolidate the purchase (Word-of-mouth advertising). Gifts are selected products from the store such as snack, stationery, chocolate, etc and will be changed each month to maintain freshness of the game. . 6 Competition Despite of having the competitive edge of location, we anticipate Buster’s will face competition from 2 areas. A) Convenience Stores This competition will be from national franchises such as 7-11 and Circle K. They have established extensive network of chain stores and are well-known to Hong Kong people. People are almost pass by two to three these conveni ence stores in their everyday life. Due to consolidation of bulk purchase, these franchises obtain strong bargaining power with suppliers for both costs of goods and payment terms. There is one 7-11 store located in the main street, 8 minutes walking distance from Sky Tower, and one Circle K in the opposite corner to 7-11. It is inevitably Sky Tower people will pass by these stores. Buster’s strategy in competing with these stores is not pricing but differentiation. ? Product flexibility Franchise convenience stores are selling standardized products regardless of demographic/geographic needs. Buster’s customer base is concentrated and focused. Products are selected according to their lifestyle, habits and preferences. We are also flexible and prompt to alter products items base on customers’ and sales feedbacks. ? Unique and high quality food and beverages Buster’s target is to have 70% of product items not identical to those convenience stores. Our tasty homemade sandwich is a typical example while other stores are selling mass produced sandwiches. ? Customers’ relationship Buster’s customers are actually our neighbors that we are working in the same building. This benefits us to build close relationship while other convenience stores focus on speedy in-and-out service. B) Plagiarist Start-up capital of lobby convenience store is comparatively lower than other main street retailing stores or franchise convenience stores. Low entrance barrier will attract people who want a start-up venture by copying the same concept as Buster’s. 5. Operation 1. Location of the business The new business venue of Buster’s will be located in the lobby floor of Sky Tower, a new office building in No. 23 Harbor Road, Kennedy District, Hong Kong. When Lydia, owner of the first Buster’s store, decided to open the second store, she had gone through serious research and calculation because location is essential to be successful and profitable. The following listed are factors why Sky Tower is the right place. ? Scale and income level of Customer base Sky Tower is an A-grade commercial building, tenants are mainly big corporations in business relating to international trading, banking and investment, insurance, accounting and etc. Anticipated total occupants will be 3,000 to 4,000. Most of them are professionals and/or high income level employees. This creates a beneficial customer base for Buster’s. ? Close by location of the two Buster’s Stores Sky Tower is just two blocks away from the first Buster’s store, this creates advantage for the owner to manage the two stores in the long run. In addition, the two stores can help each other if there is urgency for products that are out of stock. Staff can deliver the urgently needed goods to the other store within 10 minutes. ? Surroundings Sky Tower’s surroundings are also commercial buildings, with some exclusive restaurants and casual cafe. No convenience store located in adjacent buildings, just two which are 8 to 10 minutes walking distance. All these neighbors are valuable and potential for Buster’s. 2. Operation of the business A) Hours of Operation The common working hours for offices (white collar) in Hong Kong is 9:00 AM to 6:00: PM, Monday to Friday, some work on Saturday 9:00 AM to 1:00 PM. For Buster’s, business hours is 8:00 AM to 7:30 PM Monday to Friday, 8:30 AM to 2:00 PM on Saturday. Opening at 8:00AM is to serve breakfast for customers. Close at 7:30 PM is to take care of the needs for customers who are required for over-time works which is very common in Hong Kong. To ensure Buster’s employees are not exhausted by long working hours, operation will be in two-shift. The 2 employees work from 8:00 AM to 5:00 PM, and the shop manager (that is the owner) take the second shift from 10:00AM to 7:30PM. B) Service Procedures Friendly service is Buster’s emphasis and promise to our customers. This must be clearly shared with employees that without their efforts, Buster’s will not get success. They are required to follow the below listed service procedures to ensure a cheerful shopping experience to every customers. ? Greeting with smile Greet every customer with a friendly smile who enters the shop. For familiar customers, chat with them to build-up an on-going relationship. ? Serve efficiently and effectively For customers who have clear decision on what to buy, serve them efficiently. For customers who are browsing, hesitating what to buy or unfamiliar with Buster’s products, staff must to offer help by providing advices/recommendations or a brief introduction of Buster’s products according to customers’ desires. Nevertheless, no hard sale, customers are still welcomed without purchase. ? Interaction When customers prepare to pay and leave, we must to say â€Å"Thank you† and â€Å"Goodbye† with eye-contact and friendly smile. This is the last process step and interaction with customers in a transaction, it is vital to leave a cheerful image in their mind which can be deep-rooted. C) Inventory management Effective inventory management is essential for Buster’s to maintain wide variety of product items in limited space. Ultimate goal is to maintain a minimal but adequate stock and make replenishment in a weekly or bi-weekly basis depend on products’ feature and turn-over. POS system will be employed to control in-and-out systematically and to minimize human error. Cashier will input sold items automatically. Every end of the day, Christine (Shop’s supervisor) to generate and check inventory status report and pass to Shop Manager for analysis and deciding which items needed to replenish. Christine is also responsible to input data everyday when suppliers deliver goods to ensure inventory record is up-to-date. 6. Legal Issues The following listed legal documents and licenses will be well prepared and to ensure they are all completed and valid before the launch of Buster’s. Business license in partnership proprietor basis ? â€Å"Buster’s† trade mark registration ? Tenancy Agreement with Sky Tower Property Management Office ? Employment contract with the two Buster’s employees ? Purchase Medical insurance for employees ? Business Insurance Legal Consultant will be hired to ensure accuracy of legal documents and coverage . 7. Challenges A) Sustainability of Buster’s competitive edge Location is Buster’s competitive edge as we are close to the concentrated customer base. This edge will be threatened if there are any new retail tores open in the surrounding areas, they can be hypermarket or new concept food stores that tempting Sky Tower people willing to sacrifice the convenience but to walk a little bit far to try new shopping experience. B) Constantly excite customers Our customer base is young, high-income group; they have strong purchasing power that leads them to have extensive options. They pursue for premium quality and trendy commodities. It is an on-going challenge for Buster’s to keep having products that excite customers. – End –

10 Reasons Why Online Shopping Is The Best Marketing Essay

10 Reasons Why Online Shopping Is The Best Marketing Essay ABSTRACT After Internet growth, most of the dimensions of our lives such as education, business, communication, etc., were surpassed by this new phenomenon. One of these dimensions is to deal with online buying of different products and services. This paper describes the various methods of shopping and sending gifts online. This paper will also discuss the various web advertising techniques and tools used to bring traffic to the website. HISTORY In 1990 Tim Berners-Lee created the first World Wide Web server and browser. It opened for commercial use in 1991. In 1994 other advances took place, such as online banking and the opening of an online pizza shop by Pizza Hut. During that same year, Netscape introduced SSL encryption of data transferred online, which has become essential for secure online shopping. Also in 1994 the German company Intershop introduced its first online shopping system. In 1995 Amazon launched its online shopping site, and in 1996 eBay appeared. [1] PROBLEM STA TEMENT The concept of grab and wrap has established to facilitate the customers who don’t have much time to go in the market and search for different items to gift their loved ones. This website will bring all the gift items wrapped and delivered at your doorstep. All you need to do is just grab the gift and go to the party without being indulged in hassle of leaving your place, reach to the required shop, get the item, get it wrapped and then go to the party. This whole process is even worst when you are involved in office and family matters. But still, you can’t ignore this event. We will also assist in making your special days like i.e anniversary, birthdays, events a memorable one. We will provide the secure and trusted shopping and shipment mechanism by fulfilling the right orders at right time. RESEARCH OBJECTIVES In this research, we have three objectives. First Objective: The first objective of our research is to find out all the needs of customers pertaining t o online shopping. Second Objective: The second objective of our research is to provide such a marketing mechanism that would bring enough traffic into the website through affiliate programs, Google Ad sense and other social marketing networks. Third Objective: The third objective of our research is to design a model to provide the customers a secured online shopping experience. SCOPE AND LIMITATION In this research, we have analyzed different ways of online shopping and focused particularly on gifting the products and their wrapping material. This research is applicable in Pakistan and other countries similar to it in which online shopping is effective and most common mode of buying. Our products will mainly consists of the various categories that the people usually purchase for gifting purposes. The proposed model application can be implemented through google websites, different website designing platforms, or using programming languages such as HTML, ASP.NET, C#, Dreamweaver etc. The size of sample in our survey is 100. The distribution of questionnaire was done only in Karachi which might be another limitation for the research.

Analysis of Implementation of the Doctorate in Nursing Practice Degree Research Paper

Analysis of Implementation of the Doctorate in Nursing Practice Degree - Research Paper Example Doctorate level practice is one of the highest levels of nursing practice, and it involves top-notch training based on nursing science. The two categories of doctorates may coexist inside the same nursing education division. The predominant research-oriented doctorate program in nursing Ph.D., whereas the practice-focused discipline is Doctor of Nursing Practice (DNP) though recently introduced. The latter is seen as a counter-PhD because the proponents feel that former doesn’t have a practical aspect. It is for this reason that much contrary views have arisen. The inception of the Doctorate in nursing practice by the American Association of Colleges of Nursing has got some mixed reception within the nursing profession. The proponents have grounded on the fact that unlike tradition doctoral programs, the DNP program will emphasize practice-oriented direction and offer an alternative to research-oriented doctoral programs. The first reason to move to this program is due to the shifting of the nation’s intricate health-care environment. It requires high level of scientific skills and practices proficiency to provide quality treatment outcomes (Aacn.nche.edu, 2014). Various institutions such as joint commission and foundations and the institute of medicine have supported this program and called for a re-look on the nursing profession that prepares practical aspect of nursing. Another major factor that builds impetus for change of the nursing culture at doctorate level include: the speedy expansion of comprehension underlying practice; inclined health care complexities; widespread concern over patient safety and quality of health and scarcity of nursing workforce. This demands a high standard of preparation of nursing practitioner who can be able to design, assess, and evaluate patient care. The shortage of practice-focused nursing faculty has made the DNP attract increased learning expectation of nursing community to fit the existing gap.

Intellectual Property Law Essay Example | Topics and Well Written Essays - 2000 words - 2

Intellectual Property Law - Essay Example demarks whereby trademark registration acted to indicate a product’s origin or identity, while also protecting the mark from use by other traders apart from the one who registered the mark2. This solved problems that had arisen regarding showing ownership to the mark through the establishment of goodwill necessary for pass-off action. The trademark directive finally got implementation into law with 1994’s Trade Mark Act (TMA) that holds to date. It states that the proprietor of a trademark that has been registered possesses exclusive rights that are infringed upon through the use of the trade mark without their consent in the UK3. The TMA sought to widen the infringement of trademark scope through allowing traders to register any sign that could be graphically represented and capable of distinguishing one’s undertaking from another traders undertaking4. With the advent of the Trade Marks Act 1994, it has been suggested that the common law tort of passing off has become largely superfluous in the protection of identifying insignia. This paper will seek to show that this is not eh case, especially since it still acts as a fallback option when the TMA faces l imitations, while it also fills the gaps in TMA section 10. One of the reasons why the TMA has been seen to render passing-off as superfluous in protection of identifying insignia, is that it has given a broader definition to what a trademark that can be registered constitutes. This in effect has allowed the registration of most things that can be used as a distinguishing element during passing off5. However, the expanded definition provided by the TMA do not render passing off completely superfluous in English law. This is especially since it is still the main action cause for those who, for one reason or another, do not register their trademarks, as well as for those marks that are non-registerable because of the limitations of TMA. In addition, even though the TMA extends the protection scope for

CSR - corporate social responsibility Assignment

CSR - corporate social responsibility - Assignment Example While critics indicate that CSR is mostly a self-interest and PR practice with no benefits to the society (Margolis and Walsh, 2003), supporters of the concept believe that it provides value for businesses, societies and ecosystems (Porter and Crammer, 2006). According to Haigh and Jones (2006), CSR has great potential as a strategy for value addition both business and the environment if two important conditions are achieved. The first condition is that CSR has to be integrated in the company’s core strategy while the second condition is that the company should be able to monitor the additional values resulting from the CSR. Manufacturing companies, like all other businesses, have embraced the concept of CSR for its benefits. CSR is particularly important for manufacturing firms because of the impact of their activities on the environment which have been associated with pollution and climate change. Over the past two decades, CSR strategy for environmental sustainability has been made a legal requirement for manufacturing companies in most countries (Smith, 2010). One of the companies that have been affected by this is Nokia Siemens Corporation. The company has had to come up with CSR strategies both for meeting legal requirements and for its own benefits, this paper examines the CSR strategy of Nokia Siemens Corporation, benefits of the strategy, one environmental concern it has to cope with and strategies for dealing with it. Nokia Siemens Corporation has one of the most detailed and globally recognized CSR strategies for the environment which basically touches on two important areas, products and services. Every year, the company continues to search for various possibilities for reduction of the environmental impact of its devices ad operations at each and every stage of their product life cycles (Nokia Siemens Corporation, 2012). The company largely focuses on material usage, energy efficiency, manufacturing processes, and recycling. According

Course journal Essay Example | Topics and Well Written Essays - 250 words

Course journal - Essay Example For every classroom to maintain order, the parties involved must have a common behavioural code. Students can not express themselves freely without rules, and the teachers have to inform the students from the beginning of the class on how they are expected to behave. The teacher should reinforce negatively any behaviour violating the set rules. Students are motivated differently, and the teacher should make sure that the lessons taught respect the interest and goals of each student. When discussing classroom matters both genders should be present regardless of the topic being taught. When discussing or asking question, the teacher must ensure that each student participates. After focusing on the classroom dynamics and the effects they cause, I have learned that they can be handled through considering the behaviour of the parties involved. After solving the classroom dynamics, students will be able to understand the teaching and the teacher will have an easy time in handling the students. Commitment is the key to success in each subject told in class, and both teacher and students must be

Professional Affiliations Essay Example | Topics and Well Written Essays - 500 words

Professional Affiliations - Essay Example They also promote the rights of nurses in the workplace, forecasting a positive and realistic view of nursing, and by lobbying.  For instance, making their voice heard through the Congress and regulatory agencies on health care issues affecting every nurse and the public. Through the AJCC, which has been a reputable journal, members are helped not only to be at par with the modern day nursing requirement and policies but also enhance career growths. Journal is unique for it offers the latest advances in the area of clinical research, with special features. This professional body was established in 1969.The professional body is the worlds largest specialty nursing group, and assists educate nurses working in newly created intensive care units. AACN represents the interests of more than 500,000 nurses charged with the responsibility of caring for critically ill patients. The professional body is essential as a professional body since caring for critically ill patients is a critical area in nursing (Daly, 2005).   AACN also happens to be the worlds largest specialty organization representing nurses, and that makes it reputable and showcasing commitment to a nursing profession. The profession is majorly served by AACN Bold Voices and launched in July 2009. AACN Bold Voices contains concise, reader-friendly stories, reputable articles that capture the depth and breadth of critical care and acute nursing. Bold Voices carries current clinical tips along with various articles about certification and chapters. Emergency Nurses Association was founded in 1970. Initially, it aimed at networking and teaching; the professional body has evolved into an authority, lobbyist, advocate and voice for emergency nursing. The professional body currently has more than 40,000 members around the globe and is the only professional nursing association entirely

Ecommerce and Best Practices in CRM Essay Example | Topics and Well Written Essays - 2250 words

Ecommerce and Best Practices in CRM - Essay Example In addition, by changing paper-based or manual business processes with electronic methods, and by utilizing information flows in contemporary and active manners, e-commerce can improve order processing, delivery, and payment for services, products, and goods as well as minimize corporations’ inventory and operating expenses (Laudon and Laudon 25). This paper presents a detailed analysis of the e-commerce activities specially customer relationship management (CRM). The basic aim of this research is to analyze best practices in customer relationship management. The internet has become a common medium (or source) for electronic commerce (e-commerce), since it is creating up to date methods for organizations to collaborate with their stakeholders and customers. In simple words, e-commerce means carrying out business activities/operations on internet (Norton, 2001, p. 371) and (Worthington, 2003). Amazon.com is one of the most well-known examples of e-commerce. It uses e-commerce to run its business. When someone gives or submits an order at Amazon.com or even just views the web site, Amazon.com is able to scratch various online and e-mail advertisements to user’s interest. Another benefit of e-commerce that Amazon.com uses is the capability to communicate and collaborate with stakeholders and partners (Ray, 2004). This business has created a very useful web site that helps customers buy and ship chocolates. Kim Land, who is director of Godiva Direct says, â€Å"in the beginning this system was launched to make money.† And in two years, online sales have reached to more than 70 percent. This corporation successfully implemented the internet to alert the public to the exercise of catching sharks, taking away their fins for soup, and returning them to the ocean to die. In addition, the implementation of web site also helped people

Marketing Research Report Essay Example for Free

Marketing Research Report Essay Irresponsible human behaviours are impacting the environment. Therefore, environmental concern groups and also the governments around the world are trying to do something hoping to change people’s attitude towards environmentally friendly issues. This report aims at predicting the factors that motivate consumers to engage in environmentally friendly purchase behaviours. Convenience sampling of non-probability techniques was used to collect data. The data collected was then analysed by regression analysis, t-test and ANOVA. It was found out that political and technological factors have a positive relationship with environmental concern while success or anthropocentric have a negative relationship with environmental concern. Furthermore, environmental concern has a positive relationship with direct and indirect environmentally friendly behaviour and willingness to pay for environmentally friendly purchase behaviour. However, the relationships were not strong. Therefore, it is recommended that a further, more in-depth research should be conducted to find out the substantial factors that affect consumers’ environmentally friendly purchase behaviour. 1. Introduction and Background 1.1 Importance of the research In recent years, there were one after another blockbusting environmental related movie, for instances, The Day After Tomorrow in 2004, An Inconvenient Truth in 2006 and 2012 in 2009. These popular movies have undoubtedly increase people’s awareness towards climate change issues. According to World Wide Fund for Nature (2010), the average temperatures on earth have warmed by about 0.76 degree Celsius over the past 2 centuries (WWF, 2010). The increases in temperature make huge changes for the world’s climate even thought the temperature rise seems insignificantly small. Researches after researches show that this environmental problem is primarily caused by irresponsible human activities like private consumption. As a result, it is necessary for us to educate and raise the awareness of the publics so that environmental problems will not be worsening. This  quantitative research is based on the collective findings of the qualitative exploratory research conducted earlier to investigate whether or not consumers engage in environmental consideration when making consumption decisions more thoroughly. 1.2 Scope The scope of the report is to find out the factors that may affect consumers’ environmentally friendly behaviour through the qualitative research, so that marketers may make meaningful decisions based on the data collected. This research will also provide recommendations to green organisations and the federal government on how to address the environmentally unfriendly purchase behaviour. 1.3 Research problem A research problem should feasible and clear. The research problem of this research is to predict motivations that may affect consumers’ environmentally friendly purchase behaviour. 1.4 Aims and Objectives The aim and objective of this research is to look for differences between samples and come up with a conclusion. This research also aims at testing two main groups of hypotheses. 1) Social beliefs, materialism will have a negative relationship with environmental concern * The social beliefs include technological belief, political belief, economy belief, anthropocentric belief and competition belief. * Materialism includes success, centrality and happiness. 2) Environmental concern has positive indirect behaviour, willingness to pay, direct behaviour 2. Methodology 2.1 Methodological considerations and assumptions This research, quantitative research, was based on the data gather from a qualitative exploratory research which was carried out previously. The purpose of qualitative exploratory research is to narrow and clarify the scope and nature of the research problem. Exploratory research helps researchers understand the research problem and then transform ambiguous problem into well-defined ones. From the quantitative research, two groups of variables, namely materialism and social values, were identified. This  quantitative research was conducted to find out which variables may have a stronger relationship with the dependent variables which are mentioned in section 1.4. 2.2 Sample considerations The target audiences of this research are any people live in Australia and are accountable for making purchase decisions. Respondents should understand English and be 18 years old or above. However, gender, marital status and educational level of respondents are not restricted in this research. 2.3 Data collection and framework, and analytical considerations Research was conducted through survey as a follow on from exploratory research conducted by face-to-face interview. This research was conducted by using a written questionnaire on a convenience sample. Convenience sampling, which is one of the non-probability techniques, â€Å"refers to sampling by obtaining the people or units that are most conveniently available† (Zikmund, Ward, Lowe Winzar, 2007). Convenience sampling is inexpensive and quick. 1022 surveys were collected, 449 male and 573 female respondents. Since this research was trying to find out relationships between factors rather than analysing changes in a same sample, cross-sectional analysis was used. 3. Ethical Considerations In a research, ethic is one of the very important items that could not be missed. Ethics in researches are important because it supports the objective of a research, such as knowledge, truth and avoidance of error (Rensnik, 2010). Rensnik (2010) continues that ethics in a research is important also because it involves public privacy. As a result, ethical consideration has to treat carefully in a research so that the research is ethical and considerable. There are six ethical principles that have to be considered in a research according to American Marketing Association (2010), and they are responsibility, fairness, respect, transparency and citizenship. In other words, researchers have to be responsible for the consequences of their marketing decision; they also have to judge a fair balance between consumers and sellers. Furthermore, researchers have to respect human rights of all respondents involving in the research process. Researchers also have to make every effort to communicate clearly with all respondents so to strive for a high transparency of the research. Last but not least,  contributing to the community such as providing good recommendations is also considered as ethical in a research. To address all the ethical considerations above, each respondent would be asked to sign an interview consent form (see Appendix A) before the start of the survey, indicating that the interviewees do not only understands the purpose and risk of this research, but also know where to go when they have any concerns or complaints regarding the conduct of the research.

Impact of Capitalism on Global Development

Impact of Capitalism on Global Development Is geographically uneven development an inevitable outcome of capitalism? Harris (2006, p. 2) claims that in ‘examining the general character of the process of capitalist development as it has appeared historically across many different countries over a long period of time, one of its most striking characteristics is the phenomenon of uneven development.’ However we choose to define the terms ‘development’ and ‘capitalism’, it is undeniable that in recent centuries capitalism – of one kind or another – has been the dominant economic and social system throughout the world and the development has been geographically uneven – whether considered at the local, national, regional or global level. Whether the former is the cause of the latter is open to debate. Further, whether the former must necessarily cause the other, as suggested by the title question, is even less clear. This essay will first provide definitions and explanations of development and capitalism. Next it will consider the argument â₠¬â€œ most famously put forward by David Harvey, but also expounded by many others – that capitalism inevitably leads to geographically uneven development. Development can and has been defined in many different ways. Until the 1970s it was generally accepted that increasing GNP per capita was the primary – even the exclusive – objective of development. Thus development was measured exclusively in terms of GNP per capita. Since 1970, however, many criticisms have been levelled against the use of GNP as a measure of societal well-being, and various other objectives of development have been suggested to replace it. The criticisms encompass both the theoretical and the empirical, but broadly speaking they arise from the fact that use of GNP per capita as a measure of development treats economic growth as synonymous with development whereas in fact development must incorporate the enabling of individuals to achieve basic aims such as to live long, to be well-nourished, to be healthy and to be literate (Sen, 1999). Furthermore, since development was viewed in terms with GNP per capita, it was concerned with the average or aggreg ate income, rather than with the incomes of the poorest. As Arndt (1983, p. 1) explains, ‘ disappointment was increasingly widely expressed that, after two decades of unprecedentedly high rates of economic growth in most of the Third World, hundreds of millions remained in abject poverty and in many countries income distribution appeared to have worsened.’ Arndt goes on to argue that at this time, a myth emerged that something called ‘trickle-down theory’ had existed in the 1950s and 1960s, but that no development economist ever actually subscribed to any such theory. This alleged theory posits that the benefits of the accumulation of capital by the elites would ‘trickle-down’ to the masses through the creation of jobs and other economic opportunities. Whether trickle-down theory was originally part and parcel of the view of development as increasing GNP per capita, or whether it was appended to such a notion of development ex-post, it is certa inly clear that the benefits of economic growth did not trickle down to the masses. On the contrary, in fact, the world has witnessed increasing inequality. It is this inequality – or unevenness of development – with which we are most concerned in this essay. As Harvey (2005, p. 55) describes it, a ‘convergence in well-being has not occurred and geographical as well as social inequalities within the capitalist world appear to have increased in recent decades. The promised outcome of poverty reduction from freer trade, open markets and â€Å"neo-liberal† strategies of globalization has not materialized. Environmental degradations and social dislocations have also been unevenly distributed.’ Capitalism refers to an economic and social system in which the means of production are mainly privately-owned and operated for profit. It is defined by Bernstein (2002, p. 242) as ‘(a) Production of goods and services for market exchange (commodities), to make profits; (b) founded on a definitive social (class) relation between owners of capital and owners of labour power; (c) to which other social relations and divisions are linked, e.g. those of gender, urban/rural differences, nationality.’ The private owners of capital determine investment, distribution, income, production and pricing according to their own self-interest. Within these parameters, however, there are various forms of capitalism. Historically, it can be said that capitalism has gone through various stages: from merchant capitalism, through industrial capitalism; finance capitalism and monopoly capitalism to state capitalism. Further, in any stage of capitalism, any given economy can be more or less pur ely capitalist. In the world today, for example, every economy is in reality a mixed economy with elements of capitalism and elements of regulation and planning – it is the balance between free market policies and private ownership vs. regulation and public ownership that determines the extent to which an economy can be said to be capitalist or otherwise. According to Marxist accounts of capitalism, capital is created through buying commodities in order to create new commodities with an exchange value – as distinct from the use value – higher than the cost of the original commodities. Most importantly, under capitalism, labour had become a commodity itself and surplus labour is extracted by the capitalist who gains greater value from the labour (through the sale-value of the produced commodities) than the exchange value of the labour (i.e. the wage that the capitalist pays). For Marx, it was this cycle of extracting surplus labour that forms the basis of the cla ss-struggle. Harvey (see, for example, 1982, 1985, 2005, 2006) has provided what is arguably the most significant contribution to the discourse on capitalism as inevitably resulting in geographically uneven development. Harvey points to the geographic contradiction between the fixity and mobility of capital as central to understanding geographically uneven development. In order to produce value, capitalists invest in infrastructure – a form of capital with a long life and fixed location. Over its long life, this capital facilitates the production of commodities which are sold to recoup the original cost of the infrastructure and to make a profit. Meanwhile, social infrastructures are built up as the local labour force develops skills specific to the production of these commodities, relations develop between the capitalist and local suppliers, clients, politicians and banks, and knowledge is gained of local industrial processes. However, the value – or profit – produced is not spatially restricted in this way and can circulate to be invested in labour power and means of production elsewhere. Thus it may be invested in competing businesses or in different sectors of the economy. Cheaper labour and other means of production are sought and tapped in other locations within the country, in other countries in the same region, or beyond. As a result firms in a particular locality may close or reduce their level of output thus reducing employment and/or wages in the area. In turn, state agencies will receive less income through taxation, and local businesses such as those in the retail sector will suffer as the local population has less income. Home-owners may default on their mortgage payments and lenders will be forced to sell the properties at lower prices as the economy declines. Yet these state agencies, shops and shopping centres, and houses are spatially fixed – they cannot be moved elsewhere to where they could produce more value. Also, while firm s have the option to move to locations where profitability would be higher, they are also likely to have become somewhat embedded in the local area (as a result of relationships built up with customers, suppliers, employees, state officials and banks) and they have to assess the benefits of moving against the cost of building all of these relationships from scratch in a new location. The end result is the attempt (by the different stakeholders – individually or collectively) to defend exchange values in any given place to guarantee future streams of profits, wages, rents and tax revenues. Since local capitalists and local labour classes both have a vested interest in the continued existence of local industry, territorial cross-class allegiances are formed, and geographically uneven development ensues. While it is important not to conflate globalisation with capitalism since globalisation refers to a much broader process of increasing interdependence that goes far beyond the economic, Coe Yeung (2001, pp. 370-371) provide interesting input to the debate on uneven development with a consideration of globalisation, arguing that ‘one needs not be a Marxist to appreciate the uneven outcomes of the globalisation processes First, globalisation impacts differently in different sectors and industries even in the same country and/or region. While global restructuring tends to favour high tech industries, it has serious repercussions for such labour-intensive industries as textiles and clothing†¦ Second, global restructuring can produce geographically uneven impact on producers and/or countries specialising in different stages of the same production chain.’ This ties in with the explanation of how the expansion of capitalism produces new forms of unevenness, and the stagna tion of certain localities. According to Walker (1978, p. 34), for example, as capitalism expands it develops new distinctions of space thus creating a spatial mosaic of development in which none of the parts are truly independent or particularly susceptible to regional development programmes. Additionally, the expansion of capitalism intensifies its penetration of space thus increasing its mobility giving capital a strategic advantage over labour. As a result, local development becomes increasingly reliant on external capital. ‘Thus, although there is a certain evening up of development as the capitalist core expands, uneven development of a new kind necessarily emerges within what can be considered a fully developed capitalist space. This kind of unevenness is implicit in the use-value nature of capital’s relation to space, in fragmenting tendencies of the capitalist division of labor and its class hierarchy, and in the tendency of capital constantly to reduce the tim e of circulation.’ Agnew’s (2001, p. 6) perspective also demonstrates how globalization has accentuated the uneven development that results from capitalism, arguing that in this context, for example, the ‘need for rapid access to information has privileged those ‘world cities’ that have good connectivity to other places. The local availability of entrepreneurship, venture capital, technical know-how, and design capabilities differentiate ‘attractive’ from ‘unattractive’ sites for investment. At the same time, [niche] markets associated with different social groups increasingly cross national boundaries, giving rise to cross-national markets that can be served by factories located in any one of them or, for labor-intensive goods, produced wherever labor costs are lower.’ What, then, of the role of the state in today’s mixed economies? As Brenner (1998, p. 11) has pointed out, in the past century, it has been the state – and not private capital – that has planned, produced and regulated large-scale infrastructure projects (including transport infrastructure, public transport systems, utilities, energy, subsidised public housing and education systems, communications systems) to direct the ways in which labour power and capital reproduce. This highlights the fact that a purely capitalist system does not exist in any country in the world. As Harvey (1982, p. 404) explains, the state control of large-scale infrastructure enables it to direct infrastructural development differentially as the ‘territorial organisation of the state becomes the geographical configuration within which the dynamics of [infrastructural] investment is worked out.’ Thus the territorial organization of the state could in theory at least be used to channel infrastructure development in such a way as to produce geographically even – or at least more even – development. Yet Brenner (1998, p. 12) argues that in fact the state direction in practice leads to ‘new forms of uneven geographic development’ and that in so doing it produces an equilibrium. Walker (1978, p. 30) claims that geographically uneven development is indeed inevitable in advanced capitalist economies, claiming that no ‘critical observer would imagine that there is something less than systematic in the nature of capitalism producing the inevitable juxtapositions of poverty and wealth, growth and stagnation, and diverse functions in the capitalist city.’ Like Harvey, Walker claims that uneven development occurs as a result of spatial differentiation and capital mobility, two components of any capitalist system. According to Walker, (1978, p. 30), uneven development is the corollary of uneven spatial location of use-values, a nd the spatial organization of use-values is not random but is ‘a systematic product of capitalist development, varying only in form and in degree among advanced capitalist nations.’ Both Harvey and Walker provide a convincing argument for the inevitability of geographically uneven development in a capitalist system thus painting a bleak picture for development and effectively invalidating any claims of regional development programmes or any other policies aimed an evening out development. However, this last point by Walker does offer some scope for optimism. If uneven development in advanced capitalist nations varies in form and, more importantly, degree then the intuitive conclusion would be that it could vary so far that the degree of unevenness reaches zero and thus development is even. Even if in practice development can never be perfectly even, the variance in degree suggests that policies can be implemented to make development more even, if not totally even. In order to devise such policies, it is necessary to understand what aspects of certain capitalists systems have enabled them to produce more even development than others. According to Perrons (2000, p . 24), it is possible to direct policies against uneven development and to do so requires a holistic approach to social theory that explores the differences of experience in different national contexts and at different spatial scales: ‘the nature and pace of change differs between nation states and between different organizations depending on the legislative framework and social and cultural norms leading to different regional and local outcomes. Recognising and understanding these different experiences within capitalism provides a foundation for mapping alternative futures.’ If geographically uneven development is an inevitable outcome of capitalism, then we cannot hope to even out development within a capitalist world system. Short of radical calls for an overthrow of the existing system of economic and social organisation, then, policies directed at evening out development could only ever meet with partial success. However, given the importance of the state in defining and directing spaces of development, and given that every economy in the world today is a mixed economy, it must be conceivable (in theory at least) that the state could provide definition and direction in such a way as to promote even development. In order to do so, however, it is necessary to understand just what it is that causes uneven development. From the analysis above it is clear that uneven development is indeed a characteristic of capitalism; indeed it seems to be one that is inevitable. However the form and extent of that unevenness vary from place to place. Thus a better unde rstanding of exactly what determines the form and extent is necessary to reduce the extent and produced the most desirable (in other words, the least bad) form of uneven development. Bibliography Agnew, J. (2001). The New Global Economy: Time-Space Compression, Geopolitics and Global Uneven Development. Los Angeles: Center for Globalization and Policy Research, UCLA. Arndt, H. W. (1983). The Trickle-Down Myth. Economic Development and Cultural Change , 32 (1), 1-10. Bernstein, H. (2002). Colonialism, Capitalism, Development. In T. Allen, A. Thomas, Poverty and Development in the 21st Century (pp. 241-270). Oxford: Oxford University Press. Brenner, N. (1998, January 7). Between fixity and motion: accumulation, territorial organization and the historical geography of spatial scales. Chicago. Coe, N. M., Yeung, H. W.-c. (2001). Geographical perspectives on mapping globalisation. Journal of Economic Geography , 367-380. Harris, D. J. (2006). Uneven Development. Stanford University, Economics. Harvey D. (1982) The Limits to Capital, Chicago: University of Chicago Press Harvey D. (1985) The geopolitics of capitalism, in D Gregory, J Urry (eds.) Social Relations and Spatial Structures, London: Macmillan, pp 128- 163 Harvey, D. (2005). Spaces of Neoliberalization: Towards a Theory of Uneven Geographical Development . Stuttgart: Franz Steiner Verlag. Harvey, D. (2006). Spaces of Global Capitalism: Towards a Theory of Uneven Geographical Development . London: Verso Books. Perrons, D. (2000). The New Economy and Uneven Geographical Development: Towards a More Holistic Framework for Economic Geography. Economic Geography Research Group. Sen, A. (1999). Development as Freedom. Oxford: Oxford University Press. Walker, R. (1978). Two Sources of Uneven Development Under Advanced Capitalism: Spatial Differentiation and Capital Mobility. Review of Radical Political Economics , 28-38.

The Body :: essays research papers

The Body   Ã‚  Ã‚  Ã‚  Ã‚  In Castel Rock Maine, There were four boys Vern Tesio, Gordie La Chance, Chris , and Teddy Duchamp.   Ã‚  Ã‚  Ã‚  Ã‚  They have a tree house in a abandon parking lot where they play cards and hang out.   Ã‚  Ã‚  Ã‚  Ã‚  Vern comes and tells the gang that when he was under his portch looking for his penneys that he had burried when he was eight he over heard his brother talking to his friend charlie hogan about the child that was missing but they said that they did it and they said where the body was.   Ã‚  Ã‚  Ã‚  Ã‚  Gordie's brrother died in car crash.   Ã‚  Ã‚  Ã‚  Ã‚  Gordies parents never paid any attention to Gordie. There was a story that started in the book,and I didn't get it. It was a nudity scene, like a story but just started in the middle of the book.   Ã‚  Ã‚  Ã‚  Ã‚  So they each told there mom's and dad's that they were camping out in the field when they where realy going to find the dead child.   Ã‚  Ã‚  Ã‚  Ã‚  Chris brought a gun that he stole off of his dads bureau. He let Gordie see it and he told Gordie that it wasn't loaded. So Gordie pulled the trigger. And KA-BLAM. The gun was loaded and he shot the trashcans behind the diner. The waitress came out but she thought it was fircrackers. They started out on there mission walking along the train tracks.   Ã‚  Ã‚  Ã‚  Ã‚  Teddy Duchamp played chicken with the train pretending he was a paratrooper, but Chris pushed him out off the way in the nick of time. They get into a fight but settle it.   Ã‚  Ã‚  Ã‚  Ã‚  They go into the town dump to get a drink of water. It is restrickted to go in there when the dump isn't open. They fliped to see who goes to the store to get the food. when they fliped they got a goocher which vern says is bad luck, so they flip again ang Gordie looses.   Ã‚  Ã‚  Ã‚  Ã‚  Gordie goes to the store to get the food and he gets in a fight with the clerk about being gipped on the money because when Gordie add it up it came out to be less then what the clerk said.   Ã‚  Ã‚  Ã‚  Ã‚  When Gordie came back to the dump he couldn't find the guys and he noticed that the owner of the junkyard was here because his car was here. So he tried to make a run to the opposite side of the junk yard. But the man noticed him a sicked his dog Chopper after him. He made it to the other side to find his friends standing there telling him to come on.

Anger by Linda Pastan Essay -- essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  The Oxford English Dictionary defines the word anger, a noun physical affliction or pain; inflammatory state of any part of the body. Then defines anger, a verb to distress, trouble, vex, hurt, wound. In Linda Pastan’s poem â€Å"Anger† the word anger takes the action of a noun. The word anger stands out for two reasons, the author chooses it for the title, and the only sentence with anger gives the poem meaning. In the beginning of the poem the word â€Å"it† gets used many times and we don’t know what â€Å"it† refers to until she actually states the word â€Å"anger,† then we realize the â€Å"it† referred to earlier means anger.   Ã‚  Ã‚  Ã‚  Ã‚  She only uses the word â€Å"anger† once, â€Å"You whose anger is a pet dog† (pg717, line12). She chooses to finally use the word â€Å"anger† here to show the reader that the person she refers to and her ways of dealing with anger differ. The magnitude of her anger causes her to remain secretive, though she wants to tell him she knows it will only make things worse. The serious thing about her anger remains that we don’t know what causes these feelings. We only know what she states, â€Å"But mine is a rabid thing, sharpening its teeth on my very bones, and I will never let it go.† (pg717, lines14-16) This is important for two reasons, first, it is the point at which we see how the author views her anger and to what subjective nature it is relevant. Second, we come to know that her anger is also an adversary of hers, because som...

Murder Must Advertise :: essays research papers

When advertising executive Victor Dean dies from a fall down the stairs at Pym's Publicity, Lord Peter Wimsey is asked to investigate. It seems that, before he died, Dean had begun a letter to Mr. Pym suggesting some very unethical dealings at the posh London ad agency. Wimsey goes undercover and discovers that Dean was part of the fast crowd at Pym's, a group taken to partying and doing drugs. Wimsey and his brother-in-law, Chief-Inspector Parker, rush to discover who is running London's cocaine trade and how Pym's fits into the picture--all before Wimsey's cover is blown. -------------------------------------------------------------------------------- Leserrezensionen Durchschnittliche Leserbewertung: Zahl der Rezensionen: 4 Eine Leserin oder ein Leser aus New York City, USA , 1. Dezember 1999 Bravo! Knock-out Mystery! I must preface this review by confessing a bias - I'm a huge fan of Dorothy Sayers and consider it a tragedy that she did not write more detective fiction. This is definitely one of the strongest entries in the Lord Peter Wimsey series, both for mystery and entertainment value. An interesting tactic used by Sayers is to point in the direction of the culprit about three-fourths of the way through the book and then lead the reader through the detection process that actually leads to his/her unmasking. We saw this used in "Unnatural Death", also in "Whose Body?" Surprisingly, the resulting lack of suspense at the end does not deter from the mystery at all as it is fascinating to see the patient unraveling of clues and pulling together of threads that lead to evidence against a killer. It is also a better reflection of what usually happens in reality, as opposed to a lot of detective fiction where the most unlikely person did it! While we all find whodunits interestin g, the reality is that the police and private eyes are usually smart enough to figure out the most likely candidate fairly early and thus narrow their investigations. In this book, the fun is added to by the setting in an ad agency. Sayers had worked in an ad agency at some point in her career and you can see that she really knows her stuff. The interplay between the various characters is very funny and surprisingly not dated in feel, considering the book was written 70 odd years ago! I found the cricket match scene to be the most fascinating part as well the sense the reader gets that with every page, the hangman's noose is slowly closing around the killer. Murder Must Advertise :: essays research papers When advertising executive Victor Dean dies from a fall down the stairs at Pym's Publicity, Lord Peter Wimsey is asked to investigate. It seems that, before he died, Dean had begun a letter to Mr. Pym suggesting some very unethical dealings at the posh London ad agency. Wimsey goes undercover and discovers that Dean was part of the fast crowd at Pym's, a group taken to partying and doing drugs. Wimsey and his brother-in-law, Chief-Inspector Parker, rush to discover who is running London's cocaine trade and how Pym's fits into the picture--all before Wimsey's cover is blown. -------------------------------------------------------------------------------- Leserrezensionen Durchschnittliche Leserbewertung: Zahl der Rezensionen: 4 Eine Leserin oder ein Leser aus New York City, USA , 1. Dezember 1999 Bravo! Knock-out Mystery! I must preface this review by confessing a bias - I'm a huge fan of Dorothy Sayers and consider it a tragedy that she did not write more detective fiction. This is definitely one of the strongest entries in the Lord Peter Wimsey series, both for mystery and entertainment value. An interesting tactic used by Sayers is to point in the direction of the culprit about three-fourths of the way through the book and then lead the reader through the detection process that actually leads to his/her unmasking. We saw this used in "Unnatural Death", also in "Whose Body?" Surprisingly, the resulting lack of suspense at the end does not deter from the mystery at all as it is fascinating to see the patient unraveling of clues and pulling together of threads that lead to evidence against a killer. It is also a better reflection of what usually happens in reality, as opposed to a lot of detective fiction where the most unlikely person did it! While we all find whodunits interestin g, the reality is that the police and private eyes are usually smart enough to figure out the most likely candidate fairly early and thus narrow their investigations. In this book, the fun is added to by the setting in an ad agency. Sayers had worked in an ad agency at some point in her career and you can see that she really knows her stuff. The interplay between the various characters is very funny and surprisingly not dated in feel, considering the book was written 70 odd years ago! I found the cricket match scene to be the most fascinating part as well the sense the reader gets that with every page, the hangman's noose is slowly closing around the killer.

Letter to a friend regarding interesting experience in Management Class Essay

Hope all is well at your end. It has been a long time since I last heard from you. I guess you have a busy and hectic university schedule like mine which does not allow you much time apart from your course work. I don’t blame you at all because I know what a roller coaster ride this business studies really is. I am on my summer vacations now so I finally got some time to correspond with you. I would like to update you with my experience so far with my courses. I would specially like to brief you on my enthralling and interesting experience in my Management class. Business studies have an array of different courses to offer. All these courses have their application in real life, if not fully, then at least to some extent. The most common term which is associated with business people is ‘managers’ which brings us to the most basic and necessary course of Management. Management is the basic requirement of any organization and is the foundation of running a business. Without it business would be nil and there would be total chaos and catastrophe. Management has tons of practical application and offers concepts which have vast dimensions and scope. This course has been the most interesting and enthralling learning experience so far in my studies. Of course I can not give you account of the entire course but I would like to mention one very exciting and challenging activity which was conducted in the management class. This activity was regarding teamwork. You must also have learnt a lot in your engineering studies how there are different teams of engineers that take up huge scale projects. Same goes here in our business studies as well. There are various different kinds of teams such as self managed teams, cross functional teams, special purpose teams and so on. The activity which we did was regarding the most famous kind of team; problem solving team. As you must have got the idea from the name, problem solving teams or also famously known as task forces are teams that are formed especially for a problem to be solved which can not be catered to and solved by the existing organizational structure. This team brings in members varying according to the nature of the problem from different departments of the organization. This shows that problem solving teams are cross functional. (Reference for Business, 2010) The activity was conducted in such a manner that our Management course instructor first explained to us all the different types of teams which involved problem solving team as well. Then to demonstrate how the problem solving team really works in the real world he divided our class into different groups. Each group comprised of 8 members each and each group was handed a business related problem which needed to be solved. We were given a time frame of 50 minutes in which we had to come up with a plan of action to solve the problem and then we were required to present it. This was a really challenging and exciting activity. The problem which was handed to my group was that we were required to suppose a business organization that dealt in supplying of different beverages in 48 out of 50 states of U.S.   There were complaints from three major states which were Arizona, Kansas and Colorado. The major complaints were of similar nature that the supply of the beverages was not on schedule, the stock that reached to retailers was not in good condition and that the beverages supplied were not in accordance with the demand of the people. We were required to discover the reasons that why were these problems occurring in only 3 of the 48 states and what erroneous actions were responsible for these three major complaints. We approached this problem in a very professional way. We first decided upon who will lead the group and fortunately the group members general consensus was for me as a team leader. As a team leader I was the one who had to approve the final plan of action with the input suggestions and research of the different members. We decided upon that our team had members from various departments of Finance, Marketing, Sales, Research and Development and Distribution Management. We formulated our problem solving report in such a manner that first we gave a brief introduction of the problems. Then we assumed different logical reasons which could have been behind these complaints. The reasons and findings that we listed in our report were that our suppliers were categorized into 16 different teams. Each team was given 3 states for which they were responsible of supplying the beverage. One particular team was given the states of Arizona, Kansas and Colorado as they are geographically situated close to each other. As the complaints were regarding these three states hence we found that the supplier team was performing some erroneous actions due to which these complaints arose. On further imaginary research we found out the findings for each of the complaints. First we found that this team was complaint about in past as well by number of retailers regarding their lethargic attitude and poor display of punctuality. So it was found out that the team comprised of members who were irresponsible and did not meet the time restrictions of the schedule which resulted in late supply of the stock of beverages. Second complaint was due to the same reason as first. The reckless attitude of the particular team showed that they mishandled the stocks. Beverages are objects held in fragile coverings and bottles and need to be handled with care which this particular team did not display. The third complain was that of the supply not in accordance with the demand which again was due to the poor performance and reckless and untrained staff of this team. They did not record and process the orders properly which resulted in the wrong supply frequently that bothered numerous retailers. So after we had our findings we were now in position to develop a plan of action based on these findings. The plan of action was formed with collaboration with the different departments of the organization. The action decided upon to be taken was that this particular team was to be fired. Other teams would be also appraised on performance to see whether they were a source of complaints in their states or not and whether they are up to the mark or not. All those members that won’t be up to the mark would either be trained or fired. The empty vacancies would be filled by renewed hiring of the staff which would take special care that highly trained and responsible staff is hired. For the entire plan of action to carry out special assistance would be required from Human Resource Department. This concluded our entire report for the solution of problem. We then presented the whole scenario, our findings and proposed solution in front of the entire class. As Group leader I took the responsibility of presenting. It was really good experience to present in front of the entire class. The teacher appreciated our approach to the problem and gave us a few helpful additional suggestions which would give edge to our report. The class also applauded our presentation and our presentation was ranked the best in all the presentations.   All this was due to combined team effort. This was the experience I wanted to share with you. It was not just a moment of pride for me because of the best presentation, but the activity itself was so exciting and fruitful to provide us with concepts that I could not resist but share with you. I am sure you have experienced such exciting activities at your university as well. I am really looking forward to hear from you your eventful time at university. I hope you are having a good time and enjoying the studies because I think you can not learn until you enjoy you studies. Hope to hear from you very soon. I am looking forward to your reply and account of the activities at university. Hope to see you soon. Take care. Reference: Reference for Business. (2010). Teams and Team work. Retrieved May 15, 2010, from,

Paul Lutus Advertising Essay

In his article entitled Consumer Angst written in 2007, Paul Lutus claimed that â€Å"No matter how true any single advertisement is, modern advertising, taken as a whole, tells a lie — that you need the thing being advertised. † To explain his point, Paul Lutus further claims that valuable consumer goods need not be advertised because it is a necessity by itself and no promotion is needed for it to attract and obtain sales. Moreover, he explained that the quality of the product should speak for itself and there is no need to â€Å"waste company’s money asserting the obvious†. In his above-mentioned arguments, Paul Lutus obviously focuses only on one aspect of advertising which is to sell. He missed to appreciate the other function of advertising which is to inform. Advertising, as defined by Wikipedia. org, â€Å"is the form of communication whose purpose is to inform potential customers about products and services and how to obtain and use them†. The primary purpose of advertising is to create public awareness about a certain product or service that is being advertised. It aims to communicate to the intended audience that such a product or service exists. As Taflinger (1996) claims â€Å"the basic purpose of advertising is to identify and differentiate one product from another in order to persuade the consumer to buy that product in preference to another. † Advertising is usually used to create a unique image that will be identified to a product or service. The message that is being communicated usually highlights the best features of the product – its uniqueness, usability, best characteristics, etc. – that will customer’s attention to it. After providing information on the product or service features, advertising’s goal is to entice customers to try out the product. It is therefore safe to claim that the end-goal of any advertisement is to generate sales in terms of product or service. However, while it is true that every advertising campaign is aimed at generating revenue for the brand that is being advertised, it is not proper to claim that all advertisements are lies. Even premium brands such as Nike, Armani, Prada and others do advertise their products. These brands are sought after and have all proven to be of good quality. But these brands still invest on advertisement. Advertising has become an important part of today’s business. With new products sprouting like mushrooms everyday, competition has become stiff and advertising has taken a big role in allowing the product or service to compete in the market. In his article entitled â€Å"Educating the Consumer about Advertising: Some Issues† Stephen Gotlieb (1991) explains that advertising â€Å"promotes competition among producers of products and services, keeps prices low through the development of mass markets, encourages store owners to stock a variety of items, supports free expression by funding media sources, and spurs invention†. The more you are seen and understood by your customers, the bigger chance you have to stay in the mainstream. It is therefore important to get you message through, so that your product or service gets noticed. Or else, your offer will just perish. Also, with the competition getting tighter, advertisers today cannot afford to rely on false claims for their products of services. With a lot of other options available in the market, a single wrong claim will trigger the customer to try out other product. It is the role of advertising to entice customers and encourage them to try out the product. Once the customer is convinced with the advertising claim and decides to avail the product or service, it is now the role of the product to prove itself and embody what is being stated in the advertising claim. It is therefore crucial to communicate the message that best embodies the product. Once advertised, the product or service is already exposed to t he public eye and scrutiny. Unless the customer has already tried out the product or service, their perception of the product will depend on the advertisement. It will either make or break the future of the product or service depending on how you position the message about the product. Therefore, while an advertisement is typically used to create or alter the consumer’s perception of a product and induce them into buying it, it cannot be said that it is Always  a lie. For obvious reasons, advertisements only highlight the good side of the products or services. We cannot blame the advertisers to do this. While they are obviously banking on the good side of their offer, we cannot accuse them of telling us a lie. The beauty of advertising is it gives the customers the chance to evaluate the competing products or services even before purchasing it through the product claims.

Surface Perfusion Pressure Method Health And Social Care Essay

The Doppler Effect ( Doppler displacement ) is the alteration in frequence of a moving ridge ( or other periodic component ) for an perceiver traveling comparative to its beginning. It is normally heard when a vehicle sounding a Siren or horn attacks, base on ballss, and recedes from an perceiver. The frequences observed compared to the emitted frequence are: higher frequence for the receiving system during the attack ( called blue switch if we consider light alternatively of the sound ) , equal frequence when at the blink of an eye of passing by, and lower frequence during the recession ( called red displacement if we consider light alternatively of the sound once more ) . The comparative alterations in frequence can be explained as follows: when the beginning of the moving ridges is traveling toward the perceiver, each consecutive moving ridge crest is emitted from a place closer to the perceiver than the old moving ridge. Then each moving ridge takes somewhat less clip to make the perceiver compared to the last moving ridge. Consequently the clip between the reaching of consecutive moving ridge crests at the perceiver diminishes, which leads to an addition of frequence. As we can see in the figure 1 the distance between consecutive moving ridge foreparts is reduced. On the contrary, when the beginning of moving ridges is traveling off from the perceiver, each moving ridge is emitted from a place further from the perceiver than the last moving ridge, so the reaching clip between consecutive moving ridges is increased, it reduces the frequence. As we can see in the figure 1, the distance between consecutive moving ridge foreparts is increased. Figure 1: On the left side of it can be seen that if the beginning is still, an perceiver will merely see the visible radiation with the same wavelength and frequence as it was emitted. However, on the right side it can be seen what happens with a traveling beginning. ( http: //cfcpwork.uchicago.edu/kicp-projects/nsta/2007/sherman/doppler.htm ) should i compose it in mentions? The difference between the ascertained and emitted frequences is straight relative to the velocity of the beginning towards or off from you, giving: ( Eq. 1 ) is the difference between the emitted and observed frequences is the speed of the receiving system relation to the beginning: it is positive when the beginning and the receiving system are traveling towards each other, and negative when they are traveling apart.Laser Doppler FlowmetryLaser Doppler flowmetry ( LDF ) is a non-invasive diagnostic method of mensurating blood flow in tissue. This technique is based on mensurating the Doppler displacement induced by traveling ruddy blood cells ( RBC ) to the enlightening coherent visible radiation as it can be seen in figure 1. Thankss to LDF we can mensurate flux, speed and concentration of the blood cells in motion from the end product of the instrument. These parametric quantities are extracted from the power spectrum of the photocurrent fluctuations produced by reflected light lighting a photodetector. The perfusion measurings can be divided in two types: optical maser Doppler perfusion imagination ( LDPI ) and, laser Doppler perfusion monitoring ( LDPM ) ( 1 ) . In this undertaking LDPM is the m ethod used. Figure 1: the sensing of a ruddy cell flux by optical maser Dopple flowmetry. Laser visible radiation is conducted to the tegument via fibre optics. In the tegument, a little fraction of the visible radiation is reflected by traveling ruddy cells with a shifting frequence ( Doppler consequence ) , whereas the remainder is reflected by the same frequence. Both reflected beams are transmitted to the having optical fibre. ( 2 ) The major advantage of the optical maser Doppler techniques in general is their non-invasiveness and their ability to mensurate the microcirculatory flux of the tissue and fast alterations of perfusion during aggravations. The technique can mensurate perfusion quantitatively ( although relation ) in existent clip. ( 1 ) However, there are some restrictions of the technique: the influence of optical belongingss of the tissues on the perfusion signal, gesture artefact noise, unknowingness of the deepness of measuring, absence of quantitative units for the biological and perfusion zero signal ( at no flow status ) . ( 1 ) Some of them will be farther explained in the undermentioned paragraphs. Light dispersing in tissue Photons are scattered by inactive and dynamic atoms if a beam of optical maser visible radiation illuminates a little country of tissue. Therefore, the traveling RBC/RBCs? ( plural ) impart a Doppler displacement to the photon, what depends on the wavelength, the dispersing angle and the speed vector of the scatterer. Figure 3: Scattering of a photon ( wave vector qi and frequence I†° ) by a traveling RBC ( speed V ) ( reproduced from ( 1 ) ) When a moving ridge with frequence I†° is scattered from a traveling atom with speed V ( figure 3 ) , the Doppler displacement can be written as: ( Eq.2 ) qi is the incident moving ridge vector, Kansas is the wave vector of the scattered moving ridge, and I? is the angle between the speed vector and the sprinkling vector, defined as ( kI-ks ) . If I ± is the dispersing angle and I » the wavelength of the visible radiation in the medium, the Doppler displacement can be written as: ( Eq.3 ) However, there is non merely one alone Doppler displacement measuring. On one manus, in tissue with a big figure of traveling ruddy blood cells, and for sufficiently long photon way lengths, photons undergo more than one Doppler displacement, so, more than one Doppler-shifted frequence is obtained usually. On the other manus, the fact that microcirculatory blood vass have no standard orientation and randomisation of the photons with different dispersing events give rise to a scope of Doppler displacements, even if all the ruddy blood cells move at equal velocity. Hence to obtain an absolute speed measuring one needs to cognize the dispersing angle I ± , the angle between the speed vector and the sprinkling moving ridge vector I? , and the figure of Doppler displacements in the instance of multiple sprinkling. The job is solved theoretically presuming an isotropically distributed angle between the dispersing vector and the speed, furthermore, a corrected frequence spectrum is obtained as if all vectors were parallel. Finally, the end product spectrum is corrected for assorted waies of speed and besides the mention vector, by generation of the Doppler displacement by the differential coefficient of the spectrum. This last measure leads to a velocity-resolved flow measuring. ( 3 ) Depth sensitiveness The measurement deepness depends chiefly on both biological and optical facets. On one manus, it depends on the tissue belongingss such as the construction and denseness of the capillary beds, temperature, pigmentation, oxygenation, etc.. On the other manus, it depends on the wavelength of the optical maser visible radiation and on the distance between theA sending and receivingA fibres in the optical maser Doppler probe.A Since the optical soaking up by blood and, to a smaller extent, the dispersing degree of the tissue differ significantly for green, ruddy and infrared visible radiation, this may be utilized to mensurate the blood flow in tissue volumes of different size and deepness. ( 1 ) Figure 2: calculated wavelength-dependent incursion deepness of visible radiation into tissue ( blood volume 5 % , oxygenation 80 % , H2O content 80 % , ) over a wavelength scope from 500 nanometers to 100 nanometers ( reproduced from ( 4 ) ) . From figure 2 the wavelength dependance of the incursion deepness of visible radiation into tissue can be seen. Green visible radiation ( 543 nanometer ) has a smaller incursion deepness ( 0.33 millimeter ) into tissue than both ruddy visible radiation ( 633 nanometer ) and infrared visible radiation ( 800 nanometer ) , they penetrate to 3.14 millimeters and to 4.3 millimeters severally. ( 4 ) Another issue is the action of the heat, local heat regulates the tegument blood flow ( SkBF ) . In human existences local heating below hurting esthesis evokes vasodilatation, so addition of blood flow, this is mediated both by neurogenic physiological reactions and locally released substances. These interactions between the nervous mechanisms and local factors are highly complex. ( 5 ) Many factors can act upon on the response, but in general, local warming evokes an initial dilator response that peaks in a few proceedingss, followed by a brief low-water mark, and so a secondary dilation to a tableland that can be sustained. What means that the tegument is known to be innervated by two different parts of the sympathetic nervous system: an sympathomimetic vasoconstrictive system part to resting cutaneal vascular tone and a cholinergic vasodilative system having an unknown neurotransmitter coreleased with acetylcholine. ( 5 ) ( 6 ) Figure X A: representative tracing of the local warmer set temperature and the skin temperature at the local heater-skin surface interface during the local warming protocol. Bacillus: representative tracing of the tegument blood flow ( SkBF ) response to the local warming protocol. Local warming resulted in a bimodal addition in SkBF. Prolonged warming in some topics caused a gradual diminution in SkBF after 50 min. Valuess are expressed as a per centum of maximum SkBF during extract with50 millimeter Na nitroprusside. ( 5 ) As we can see from Figure 1A there are distinguishable responses to the local warming. In human existences the skin temperature is about 30 grades, so, if it is heated until 40 and remained changeless as it is done in ( B ) two responses are clearly seen. The flow before the warming is called baseline flow, after warming, a rapid addition in SkBF is found. After a transeunt bead follows and eventually a secondary progressive rise to a tableland is found. After drawn-out warming ( 50 min ) , SkBF begins to worsen in some, but non all, topics despite the care of an elevated tegument temperature. ( 5 ) I have to associate this to the minuts that I chose for my measurings! ! ! ! ! The last facet to reference is the altering the source-to-detector separation, measurings with a flow theoretical account showed that a larger separation between beginning and sensor increased sensitiveness to deeper flows, whereas a smaller separation between beginning and sensor steps more superficially. ( 7 ) Human tegument is the largest organ of the organic structure and has an mean thickness of 1-2 millimeter. LDF mensurating deepness is in the order of 0.5-1 millimetre. Sing incursion deepness and source-to-detector separation and in order to make this deepness a investigation with standard fibre separation ( 0.25 millimeter ) , and a 780 nm wavelength optical maser are used in this undertaking. ( is it ok if I mention this facet of the undertaking already? ) Furthermore, we have chosen the investigation PROBE 457 ( 357 ) Angled Small Thermostatic Laser Doppler Probe to be able to heat the tissue and therefore, the effects of the temperature can be studied. Calibration Standardization is required in comparing the degree of perfusion in different measurings and from different instruments owing to the fact that the optical maser Doppler perfusion signal is a comparative step of flux. Then, we can look into the instrument ‘s stableness, set up the one-dimensionality of the instrument ‘s response to blood flow, set up relationships between different instruments, and associate the reading of the instrument to existent perfusion ( if it is possible ) . There is no gilded criterion until now available for the standardization of the optical maser Doppler instrument for perfusion measurings. The job is that the distribution of blood vass in tissue and optical belongingss is heterogenous, hence it is hard to graduate an instrument to mensurate absolute blood flow per unit volume of tissue. Even though is non the aimed gold criterion, a simple method has been in usage for frequent and easy standardization of optical maser Doppler instrumentality. It is about an aqueous suspension of polystyrene microspheres in Brownian gesture called a motility criterion. The Doppler displacement generated by the atoms in Brownian gesture is used to graduate the system ‘s overall unity for a comparing of measurings at different clip intervals. In our undertaking the investigations are calibrated sing the Brownian gesture of our atoms equal to 250 perfusion units ( PU ) . In our measurings, since no current optical maser Doppler instrument can supply absolute perfusion values ( e.g. ml/min/100 gram tissue ) measurings will be expressed in as Perfusion Units ( PU ) , which are arbitrary. Calibration is required therefore a particular motility criterion PF100 developed by Perimed is used for this undertaking.Skin Perfusion Pressure ( SPP ) methodSkin Perfusion Pressure ( SPP ) is a noninvasive method to mensurate the blood force per unit area of the microcirculatory flow in the tegument at a 1-2mm tegument deepness. SPP measures in millimetres of quicksilver ( mmHg ) the force per unit area at which blood flow foremost returns to the capillaries. Figure X, proctor, turnup and Doppler investigation set-up for SPP. ( I do non like it, I will utilize my exposures ) Skin Perfusion force per unit area is performed by puting a proctor of microcirculation ( in our instance is Laser Doppler investigation ) on the tegument ( see figure X ) , puting a force per unit area turnup on it and blow uping the force per unit area turnup until the microcirculation disappears. Then, the air leaves the force per unit area turnup easy until the microcirculation appears which can be seen by the optical maser Doppler signal on the proctor of the first channel, figure X. Figure Twenty: the microcirculation displacement by the optical maser Doppler can be seen in the first channel, the signal disappears when the force per unit area in the turnup is increased ( impart three ) to barricade the microcirculation at 40 grades, skin temperature by the 2nd channel. When the force per unit area in the turnup decreases, the force per unit area on the tegument returns at one point, the SPP ( T flag ) . The force per unit area in the force per unit area turnup at the clip the microcirculatory flow returns is defined as the SPP at that point of the tegument, on the instep portion of the pes in the instance of figure X. The SPP in mmHg is pointed out in the 3rd channel of figure XX. Even though the best organic structure place on skin perfusion force per unit area in patients with terrible peripheral arterial disease ( see pag X ) is in the sitting place after the pes had been lowered vertically for 10 min, the chief demand is that the height degree of the mensural portion coincides with the degree of the bosom ( 8 ) . The measurings in the undermentioned undertaking are taken at supine place since the voluntaries are healthy and it is a comfy place. SPP value is a mention value that measures the chance of healing of hurts and ulcers related to the force per unit area measured on the tegument every bit good as diagnosings CLI and PAD diseases. There have been several statistical surveies about SPP cut-off value as we can see in table Ten, sum uping the interval between 30-40 mmHg is the critical scope, below ulcers and hurts will now mend, above they will. ( 9 ) ( 10 ) ( 11 ) ( 12 ) ( 13 )ReportStandardsConsequenceCastronuovo, Adera, Smiell and Price, 1997 & lt ; 30 mmHg Command line interface Lo, Sample, Moore and Gold, 2009 & lt ; 30 mmHg lesion unlikely to mendAa†°? 30 mmHg lesion probably to mend Yamada, Ohta, Ishibashi, Sugimoto, Iwata, Takahashi and Kawanishi, 2007 & lt ; 40 mmHg lesion unlikely to mend and severe PADA& gt ; 40 mmHg lesion probably to mend Adera, James, Castronuovo, Byrne, Deshmukh and Lohr, 1995 & lt ; 30 mmHg lesion unlikely to mendAa†°? 30 mmHg lesion probably to mend Table Ten: Reference SPP values for healing and for foretelling CLI and PAD. If the patients suffer of sphacelus, ulcers and/or there is a demand of amputation for other grounds, SPP is a tool to demo with great truth if the hurt would mend or non. A survey shows experimental consequences sing SPP cut-off value when make up one's minding on amputation when enduring from ulcers ( see figure XXXX ) . Figure XXXX: SPP values for all limbs. Group I patients ( n = 32 ) required vascular Reconstruction or major amputation in the sentiment of vascular go toing sawbones. Group II patients ( n = 29 ) were non thought to necessitate vascular Reconstruction to mend and were managed with local debridement, minor amputation, or both. All foot lesions and amputation lesions in group I healed ( reproduced from ( 10 ) ) Figure XXXXXV: Logistic arrested development analysis of patients ( n=29 ) that were non thought to necessitate vascular Reconstruction to mend and were managed with local debridement, minor amputation, or both correlating a given SPP with chance of mending. ( 10 ) From figure XXXXXV it can be seen that SPP values between 20 and 30 millimeter Hg do non foretell mending with great truth. But an SPP value less than 20 mm Hg and an SPP value greater than 30 mm Hg predict the result of local therapy rather accurately. ( 10 ) SPP is non changeless in all organic structure skin surface, as it can be seen in the tabular array below. SPP is normally lower the further of the bosom, therefore it consequences with a really low value when patients suffer from CLI and PAD.DegreeNormal Mean SPPIschemic mean SPPBrachial 52A ±3 55A ±8 Above Knee 50A ±5 46A ±4 Below Knee 42A ±4 22A ±4 Dorsal pes 43A ±4 10A ±2 Dorsal toe 55A ±5 16A ±4 Plantar toe 73A ±5 17A ±3 Table Thirty: different SPP values in both healthy and ischaemic voluntary limbs ( reproduced from ( 14 ) ) .ApplicationsFalten bibliografiesssssssssPeripheral Arterial Disease ( PAD )Peripheral vascular disease ( PAD ) is a narrowing of blood vass that restricts blood flow. It largely occurs in the legs, but is sometimes seen in the weaponries. More restrictedly speech production, PAD includes a group of diseases in which blood vass become restricted or blocked. Typically, the patient has peripheral vascular disease from artherosclerosis, which is a disease in which fatty plaques form in the interior walls of blood vass. Blood coagulums are another procedure taking to PAD, which restrict blood flow in the blood vass. In some instances PAD may happen all of a sudden if an intercalation or when a smudge coagulum quickly develops in a blood vas already restricted by an atherosclerotic plaque, and the blood flow is rapidly cut off. Even thoguh venas and arterias can be affected, but the disease is normally arterial, that is why is called PAD. The chief symptom is pain in the affected country. Since this disease is seen chiefly in the legs, the hurting and other symptoms normally occur when walking. The symptoms may vanish when resting. As the disease becomes worse, symptoms occur all the clip, even at remainder. At the most terrible phase of the disease, when the blood flow is greatly restricted, sphacelus can develop in those countries missing blood supply. There are different phases harmonizing to the badness of PAD. These phases were classified by Fontaine and Rutherford, they can be observed in the undermentioned talbesxXX X. Phase I – Asymptomatic. Phase II – Intermittent lameness. This phase takes into history the fact that patients normally have a really changeless distance at which they have pain. Phase IIa – Intermittent lameness after more than 200 metres of hurting free walking. Phase IIb – Intermittent lameness after less than 200 metres of walking Phase III – Rest hurting. Rest hurting is particularly disturbing for patients during the dark. Stave IV – Ischemic ulcers or sphacelus ( which may be dry or humid ) . Table ten: Different Fointaine categorization phases to sort PAD. Phase I – Asymptomatic Phase II – Mild lameness Phase III – Moderate lameness – The distance that delineates mild, moderate and terrible lameness is non specified in the Rutherford categorization, but is mentioned in the Fontaine categorization as 200 metres. Phase IV – Severe lameness Phase V – Rest hurting Phase VI – Ischemic ulceration non transcending ulcer of the figures of the pes Phase VII – Severe ischaemic ulcers or blunt sphacelus Table Twenty: Different Rutherford categorization phases to sort PAD There are several factors that may increase the chance of PAD for case: smoke, diabetes, fleshiness ( a organic structure mass index over 30 ) , high blood force per unit area ( 140/90 millimetres of quicksilver or higher ) , high cholesterin ( entire blood cholesterin over 240 mgs per decilitre, or 6.2 millimoles per litre ) , increasing age ( particularly after making 50 old ages of age ) , high degrees of homocysteine ( a protein constituent that helps construct and keep tissue ) and a household history of peripheral arteria disease, bosom disease or shot. ( 15 ) About the diagnosing, PAD can be diagnosed by comparing blood force per unit areas taken supra and below the point of hurting. The country below the hurting ( downstream from the obstructor ) will hold a much lower or undetectable blood force per unit area reading. There are several techniques to name PAD, the most common used in the infirmaries are Ankle-brachial index ( ABI ) , computed Tomographic Angiography ( CT ) , Magnetic Resonance Angiography ( MRA ) , Doppler and Ultrasound ( Duplex ) imagination, Angiography, and Skin Perfusion Pressure ( SPP ) . I will shortly specify them subsequently on this undertaking. If the individual fumes, it is extremely recommended to halt smoke instantly. Exercise is basic to tret PAD. Infections in the affected country should be treated quickly. Surgery may be required to try to handle clotted blood vass. Sing the last phases, limbs with sphacelus must be amputated to forestall the patient to decease. * 5. Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL et Al. ACC/AHA 2005 guidelines for the direction of patients with peripheral arterial disease ( lower extermity, nephritic, mesenteric, and abdominal aortal ) : executive summary a collaborative study from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interverntions, Society for Vascular Medicine and Biology, Society of Interventional Raidology, and the ACC/AHA Task Force on Practice Guidelines ( Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease ) endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation ; National Heart, Lung, and Blood Institute ; Society for Vascular Nursing ; Transatlantic Inter-Society Consensus ; and Vascular Disease Foundation. J Am Coll Cardiol 2006 ; 47:1239-312. WHAT HAPPENS IS IT IS A REFERENCE OF A REFERENCE? ?Critical Limb Ischemia ( CLI )Critical limb ischaemia is defined as limb hurting happening at remainder, or impending limb loss caused by terrible via media of blood flow to the affected appendage. Although the trademark of peripheral arterial occlusive disease is an unequal blood flow to provide critical O demanded by the limb, critical limb ischaemia ( CLI ) occurs merely after chronic deficiency of blood supply, puting off several pathophysiologic events that finally lead to trophic lesions or rest hurting of the legs, or both. ( 15 ) The international consensus about CLI is the undermentioned: any patient with chronic ischaemic remainder hurting, ulcers, or sphacelus attributable to objectively turn out arterial occlusive disease. ( 16 ) It is to be stated that CLI is non to be confused with acute occlusion of the distal arterial tree, alternatively it is a procedure that occurs in a scope frame of months to old ages and, if left untreated, it leads to limb loss secondary to miss of equal blood flow and oxygenation through the distal appendages. ( 15 ) CLI is a terrible manifestation of PAD, so, the patients would be classified in the more terrible terminals of the Fontaine ( present III-IV ) or Rutherford categorization ( grades V-VII ) , seetables X and XX severally. Figure Ten: SPP method measures the chance of mending related to the force per unit area measured on the tegument every bit good as diagnosings CLI and PAD. ( from Vasamed AB, company, non article, it is merely a powerpoint page of a presentation of a company ) ( can I utilize it? ) SPP can name both CLI and PAD therefore, they can be treated. Which is of high relevancy if we consider the high mortality of these diseases.Alternate methods to SPPIn order to name both PAD and CLI several methods can be used, they are the undermentioned: Ankle-brachial index ( ABI ) : A a non-invasive method that compares the blood force per unit area in the pess to the blood force per unit area in the weaponries to find how good the blood is fluxing. Normally the ankle force per unit area is at least 90 per centum of the arm force per unit area, with terrible contracting it may be less than 50 per centum. If an ABI reveals an unnatural ratio between the blood force per unit area of the mortise joint and arm, more testing Is needed before doing a diagnose. Computed Tomographic Angiography ( CT ) : a non-invasive trial that shows the arterias in the venters, legs and pelvic girdle. It is peculiarly utile in patients with pacesetters or stents.A A Magnetic Resonance Angiography ( MRA ) : a non-invasive trial that gives information similar to that of a CT without utilizing X-rays.A Doppler and Ultrasound ( Duplex ) imagination: a non-invasive method that visualizes the arteria with sound moving ridges and measures the blood flow in an arteria to bespeak the presence of a blockage.AAAngiography: ( by and large reserved for usage in concurrence with vascular intervention processs ) an invasive method that consists on inject a contrast agent into the arteria and X raies are taken to demo blood flow, arterias in the legs and any obstructions that may be present.1ST Part: TEMPERATURE DEPENDENCE OF SPPQuestionhypertext transfer protocol: //dwb.unl.edu/teacher/nsf/c01/c01links/www.science.mcmaster.ca/biology/4s03/thermoregulation.html RESPONSES TO HEAT: When the organic structure is exposed to heat ( Sun, fire, excessively much vesture ) , body temperature rises. Skin heat receptors and blood convey these alterations to the hypothalamic thermoregulator. The thermoregulator inhibits the sympathomimetic activity of the sympathetic nervous system, which control vasoconstriction and metabolic rate, therefore doing cutaneal vasodilation and cut downing BMR. This causes an addition in heat loss via the tegument and a lessening in heat production in the nucleus. If the heat is sufficiently intense, the cholinergic sympathetic fibres, which innervate perspiration secretory organs release ACh, exciting perspiration. Sweating is the most effectual nonvoluntary heat contending response in adult male. Behavioral responses to heat, such as lassitude, resting or lying down with limbs spread out, decreases heat production and increases heat loss. Wearing loose and light vesture, fanning and imbibing cold drinks besides helps wit h heat loss. 40 grades ( a temperature that opens more capillaries, so it is thought that it could increase the An increment vasodilatation and decrease of BMR can increase the flow, so the Doppler signal would be increased. It is something to be tested but the chief inquiry is if these metabolic alterations will act upon SPP. If the optical maser Doppler would merely increase the signal with no alteration of SPP, it would be an tremendous aid for the doctors to acknowledge the SPP value on the monitored information. This old inquiry is to be tested and discussed carefully.SET-UPPF 472 digital/analog convertorA convertor from linear signal to digital signal will be needed in the 2nd portion of the measurings. It is present even though it is non needed in our first portion.PF 5000 Doppler proctor which includestwo PF 5010 Laser Doppler Perfusion Monitoring ( LDPM ) unitsThe PF 5010 LDPM Unit is used for blood perfusion measurings based on optical maser Doppler engineering. Laser Doppler measures the sum, local microvascular flow including capillaries, arteriolas, venulas and shunts. Each unit i ncludes one optical maser Doppler investigation.PF 5020 Temperature unitThe PF 5020 Temperature Unit is used toA execute local heat aggravation and/or temperature measurings. The PF 5020 unit has two connections for either thermostatic optical maser Doppler probes and/or temperature measuring detectors.one ( Numberss or letters ) PF 5050 Pressure UnitThe PF 5050 Pressure Unit is used to command additive or instant turnup force per unit area deflation. It has been developed to simplify and standardise trials such as Skin Perfusion Pressure ( SPP ) .Computer with Perimed PSW 2,5 packagePSW 2,5 package will let to obtain the measurings of the PF 5000 Doppler proctor numerically.Pressure turnups 10 centimeter and 12 centimeters HokansonA force per unit area turnup is a device that shows the force per unit area in mmHg inside the cuff chamber. The breadth required will depend on the breadth of the mark to be measured. The turnup should be 20 % wider than the mark. In our instance, the ma rk is the in-between calf. hypertext transfer protocol: //www.deh-inc.com/userfiles/image/SC12D % 20PP.jpgPressure pump WelchAllyn 2005A force per unit area pump will pump air into the force per unit area turnup.457 ( 357 ) Angled Small Thermostatic Laser Doppler ProbeProbe 457 is a combined optical maser Doppler and thermostatic investigation used for local heat aggravation while blood perfusion is measured. Its optical fibers are integrated in the het country and therefore the whole tissue country under the investigation will be heated. Its fibre separation is 0.25 millimeter. investigation 457457 Probe SupportA support is required in order to enlarge the country of the investigation therefore avoid tilting and increase contact with the investigation. ( our sentiment until the following experimentsssssssss ) ? ?PF 105-3 double-sided adhesive stripsStrips are used for arrested development of the tegument and the investigationPF 1000 Calibration DeviceAqueous suspension of polystyrene microspheres in Brownian gesture used for the standardization of the investigations in this undertaking. Photosssss, cameraaaaaaaaMethodTo get down with, the measuring devices have to be calibrated. The optical maser Doppler investigation is calibrated by a motility criterion obtained from Perimed. Since the signal from PF 5000 Doppler proctor is so sent to the PF 472 digital/analog convertor before making the computing machine, so, laser Doppler signal, temperature and force per unit area have to be calibrated every bit good. It is easy since the Numberss are shown in the proctor, so an easy correlativity can be found. Skin Perfusion force per unit area is performed by puting a proctor of microcirculation ( in our instance is laser Doppler investigation ) on the tegument, in our instance is placed in the in-between calf as it is showed in figure Ten. ( PHOTO ) . In our instance we will antecedently line-up the 457 Probe Support, it is obvious that a support will convey more stableness, avoiding tilting and increasing the contact with the investigation? A? . Furthermore, by a Micrometer? A? a degree of 0.5mm of difference has been found between the standard support and the investigation. Perimed employees have lined it up. Then, the force per unit area turnup is placed on the Doppler investigation 457 which is contained inside the lined-up support, being careful that the turnup has the investigation precisely in the center of the blow uping rectangle as it can be seen in figure X. The following measure is taken when the received signal from the optical maser Doppler investigation is regular and familiar, as it can be seen in figure Ten. When can get down the measuring once we receive a regular signal ( basal? A? ) from the optical maser Doppler investigation, so, the force per unit area turnup is inflated until the microcirculation disappears, see figure X. Figure X The three channels are shown through PSW 2,5 package: Doppler laser signal ( perfusion units, PU ) , temperature signal ( Celsius grades ) , force per unit area of the force per unit area turnup ( mmHg ) . The first channel shows the alteration of the optical maser Doppler from a normal flow signal to a low cubic decimeter flow signal. The 2nd channel shows the changeless temperature of the voluntary, 30,9 Celsius grades. ? grades Celsius? The 3rd channel shows how the force per unit area turnup is inflated to accomplish low flow circulation. Then, around 30 seconds are needed in order to stabilise the circulation, so until we get a regular signal from the optical maser Doppler investigation ; hence a level and humdrum signal is obtained. Consequently, the air can be let out by the force per unit area turnup easy until the microcirculation appears as it can been in figure X, which can be seen by the optical maser Doppler signal on the proctor from figure X. The force per unit area in the force per unit area turnup at the clip the microcirculatory flow returns is defined as the SPP. This modus operandi is repeated three times at skin temperature ( 20-35 ( look at the values obtained! ) degrees Celsius ) Figure X The three channels are shown through PSW 2,5 package: Doppler laser signal ( perfusion units, PU ) , temperature signal ( Celsius grades ) , force per unit area of the force per unit area turnup ( mmHg ) . The first channel shows the alteration of the optical maser Doppler from a low-flow signal to a normal flow signal. The 2nd channel shows the changeless temperature of the voluntary, 30,9 Celsius grades. ? grades Celsius? The 3rd channel shows how the force per unit area turnup is easy deinflated and the SPP is pointed out and the Afterwards, the Doppler investigation is heated until a temperature that brings a vasodilatation response ( addition of optical maser Doppler signal ) without hurting ( B ) ! ! ) , 40 grades Celsius. Even though 15 proceedingss are needed harmonizing to ( KRISTIANNN! ) , around two proceedingss will be considered in order to open a important measure of capillaries since in infirmaries the continuance of the trial plays an of import function when taking the medical method to be used. Then, 3 more measurings with the old modus operandi are taken at this new temperature, 40 grades Celsius. Following, the systolic force per unit area is measured in all the voluntaries merely as a standard cheque. hypertext transfer protocol: //www.aqualyte.com.au/pdf/PHYSIOLOGICAL % 20RESPONSE % 20TO % 20HEAT % 20EXPOSURE.pdf ( non used, but may be needed )ConsequenceHere follows the list of the 25 voluntaries, with a sum of 28 battalions of measurings. Measurements in the same voluntaries were taken in different yearss. For each voluntary, as it is explained in the Method, 3 recordings are taken and averaged at Tvolunteer, plus 3 recordings are taken an averaged at T=40 grades C.Volunteers:NameAgeWeightGenderAnders 42 86 adult male Anders W.AAadult male Asa 48 55 kvinna Bjorn 51 91 adult male Cia 52 70 kvinna Eva 56 53 kvinna Han dynasties 50 79 adult male Hans-Erik 49 77 adult male Jan 58 86 adult male Kjell 75 85 adult male Kristian Euren 49 88 adult male Kristian Euren 2 49 88 adult male Microphone 48 87 adult male Dent A 36 A 100 adult male Niklas 35 80 adult male Oskar 30 92 adult male Patrik 31 70 adult male Per 42 72 adult male Peyman 38 81 adult male Reyhan 28Akvinna Reyhan 2 28Akvinna Sara 33 64 kvinna Susanne 35 54 kvinna Susanne 2 35 54 kvinna Sven 55 73 kvinna Thomas B. 48 63 adult male Thomas C. 36 75 adult male Table: voluntaries ‘s name, age, weight and gender.a ) SPP vs temperature and clip-interesting consequences for our undertaking can be found in the tabular array in the Annex, here? -all the consequences obtained ( Wizard Reports ) can be found in the Annex? The chief goul in this portion of the undertaking is to cipher if the Temperature is a factor that influences the SPP, the influence of clip will be studied at the same clip. During the recordings a somewhat addition of the SPP values at the same temperature was noticed for each measuring. In order to explicate it and to seek to avoid this factor act upon our decisions about the temperature, the difference between the first recorded value and the undermentioned values ( until 6 recordings ) for each measuring has been calculated to get down with. The consequences are plotted on figure Ten. Figure X: Pressure difference between the first value in each measuring, and the undermentioned ( until six ) , in each measuring. With a sum of 26 measurings. In order to do the consequences and farther decisions of the graph X more clear, an norm of the differences between the first recordings and the remainder of the recordings for all the 26 considered measuring is calculated and used for farther computations in table Ten.average value difference between the 1st recording and the 2nd ( Tvolunteer )4,75 mmHgaverage value difference between the 1st recording and the 3rd ( Tvolunteer )6,15 mmHgaverage value difference between the 1st recording and the 4th ( T=40 d C )9,56 mmHgaverage value difference between the 1st recording and the 5th ( T=40 d C )9,15 mmHgaverage value difference between the 1st recording and the 6th ( T=40 d C )11,15 mmHgTable Ten: average value differences between the 1st and the remainder recordings in each voluntary. From the table Ten we can see that all values of SPP addition on clip and non merely between the 3rd and 4th recordingS, when the temperature is increased till 40 grades. The biggest difference is between the 1st and the 2nd. Just to do certain that it is non an mean artefact, it is deliberate how would alter the deficiency of the first measuring on the overall consequence at Tvolunteer, without warming, see figure XX. Figure Twenty: average values at Tvolunteer, sing merely the 2nd and the 3rd recorded values in each measuring vs sing all three Tvolunteer values obtained. Decision: the 1st value could be excluded. After ciphering the influence of the clip on the recordings and in order to analyze the influence of the temperature on the SPP consequences, the undermentioned consequences will be considered both excepting the first recordings for each measuring, and without excepting them. 156 recordings realized and averaged. 78 averaged values used for farther computations. A Bacillus C 1ST, 2ND, 3d averaged entering values. Tvolunteer 4TH, 5TH and 6TH averaged entering values. T=40 degrees Celsius 2ND, 3RD averaged entering values. Tvolunteer 62,2 68,0667 64,5 60,6 63,2 61,55 38 47,7667 38,8 906 96,8667 88,15 783 95,55 88,15 57,8 68,7333 62,4 532 61,9333 56,8 508 57,3667 54,35 57,6 61,8333 59,7 56,7 55 55,8 81,4 87,2333 82,05 42,8 55,3333 38,4 59,8 59,1333 60,15 61,5 69,6667 61,25 43,0 51,8667 47,3 70,7 77,5333 72,4 77,3 75,25 77,55 58,6 64,4667 57,85 53,6 59,0333 55,8 523 56,3 54,65 60,5 63,3667 60,3 36,1 48,8667 39,5 44,3 47,4 46,2 73,0 82 77,1 69,1 75,3 73,75 90,9 95,8333 93,35 table ten: averaged values in each voluntary depending on the temperature recorded, A at Tvolunteeer. B at T=40. C, at Tvolunteer excepting the 1st recording. The first chief consequence from this first portion will ensue from deducting B-A and averaging the ensuing vector. The 2nd, from deducting C-B. Thus an overall position of the influence temperature can be understood.B-A=6,32 mmHgaverage value of the averaged T=40degrees-values, subtracted from all six Tvolunteer-values.C-A= 4,5 mmHgaverage value of the averaged T=40degrees-values, subtracted from the Tvolunteer-values ( excepting the 1st recorded value ) .B ) Baseline V T and clip ( baseline? Stabile phase? ; how could I explicate that? )In this portion the baseline of both laser Doppler signal ( PU ) and from the turnup ( mmHg ) are studied. Just before pumping both a stable optical maser and force per unit area signal are wanted. Once pumped, after few seconds ( even though 30 sec have been considered in instance ) both signals are stable once more. We have seen that the SPP value is lightly increasing along the recording. The inquiry is if baseline is increasing every bit good or if it is changeless along the measuring, along the recording of the 6 SPP values ( the 3 first recordings at Tvolunteeer, and the 3 following recordings at T=40 grades C ) . First, the optical maser Doppler signal received is studied. The signal should be expected to be higher when the temperature is increased in the tegument surface, accordingly, the alterations of flow can be more ascertained and therefore the obtainance of SPP is simpler. Merely the 10 first measurings are taken into history for the computations. We will analyze it during Tvolunteer and T=40 grades Celsius. From the tabular array X ( ANNEX ) , we can see the consequences of PU in each of the stairss, extracted from the â€Å" Wizard studies † : TvolunteerAAAAAAAAAAAT=40 grades CAAAAAAA1st pumping 1st stabilisation 2nd pumping 2nd stabilisationA3th pumping 3th stabilisation 4th pumping 4th stabilisations 5th pumping 5th stabilisations 6th pumping Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium mmHg Plutonium 7,94 117,29 17,58 0,06 4,67 124,93 19,82 0 4,84 132,99 100,93 0 6,18 137,94 46,74 0 6,21 130,85 49,31 0 6,98 5,74 148,17 14,14 1,35 6,03 146,75 14,61 0,03 6,58 139,49 38,12 0 6,8 139,44 32,49 0 6,65 154,31 25,15 0 6,43 4,85 144,22 14,65 2,94 5,31 153,1 12,48 0,94 5,21 135,74 30,76 0 5,41 146,66 27,65 0,21 5,21 141,12 30,27 0,3 5,34 5,01 137,77 23,79 0,43 4,91 133,32 24,12 0,4 5,1 140,34 33,16 0 5,36 129,5 26,6 0,48 5,2 132,77 28,5 0,5 5,24 2,86 145,89 15,62 0,84 3,19 138,54 11,93 0 3,27 139,53 34,66 0 3,58 148,84 27,68 0 3,63 149,15 29,23 0,39 3,65 5,01 137,77 23,79 0,43 4,91 133,32 24,12 0,4 5,1 140,34 33,16 0 5,36 129,5 26,6 0,48 5,2 132,77 28,5 0,5 5,24 5,2 147,06 17,32 0,47 4,97 154,36 17,05 1,06 4,94 138,69 45,79 0,01 5,34 147,44 40,16 1,29 5,75 128,04 45,72 1,43 5,95 5,51 142,98 21,32 1,09 6,57 136,24 18,15 1,24 5,76 145,81 58,47 0 5,68 141,28 37,53 1,78 5,49 137,24 34,87 1,16 5,87 6,67 151,08 11,93 1,46 6,36 138,32 11,33 0,25 6,02 129,92 36,08 0 6,71 135,67 29,24 0,5 6,37 143,39 41,29 0 6,65 5,6 116,37 18,12 0,38 6,12 123,72 20,55 0,2 5,36 139,05 15,56 0,4 4,45 121,43 21,44 0,87 4,39 118,44 19,94 0,51 4,27 Table X ( possibly let ‘s set in the extension? ) To mensurate the stableness during pumping and non-pumped, the wired norm for each measure is calculated for all 10 measurings, at Tvolunteer:A=2ND PU pumped value -1st PU pumped valueB=3th PU pumped value 1st PU pumped valueAt T=40 grades C:C=4th PU pumped value -1st PU pumped valueD=5th PU pumped value -1st PU pumped valueE=6th PU pumped value -1st PU pumped valueNow, averaging each vector obtained: A -0,135 Bacillus -0,221 C 0,048 Calciferol -0,029 Tocopherol 0,123 Table Ten: mean values of laser signal of all the stabile stairss for all the voluntaries in the pumped stabile phase. It can be seen from table Ten that neither the addition on temperature nor the development on clip are relevant on the PU signal while pumped ( occlusion ) . Then, no farther computations will be taken. Now we consider the measurings of PU on the stabile period before and after the pumping of the turnup, were the first measuring is after the first pumping. At Tvolunteer:F=2ND PU stabile value -1st PU stabile valueG=3th PU stabile value – 1st PU stabile valueAt T=40 grades C:H=4th PU stabile value -1st PU stabile valueI=5th PU stabile value -1st PU stabile valueAs expected from ( bibliographty? ? ? A? ) the addition of T leads to a better signal PU as can be seen in G, H, I vectors. Now, averaging each vector obtained: F -0,41 Gram 24,843 Hydrogen 13,787 I 15,452 Table Ten: mean values of laser signal of all the stabile stairss for all the voluntaries in the unpumped stabile phase. As expected from ( bibliographty? ? ? A? ) the addition of T leads to a better signal PU as can be seen in G, H, I averaged vectors. To complete with this portion the force per unit area ( mmHg ) is studied. Again, merely before pumping a stable force per unit area signal from the turnup is wanted. The inquiry is if this stableness is changeless along the measuring, along the recording of the 6 SPP values. Merely the 10 first measurings are taken into history for the computations. We will analyze it during Tvolunteer and T=40 grades Celsius. If now we consider the measurings of force per unit area on the stabile period before and after the pumping of the turnup, were the first measuring is after the first pumping. At Tvolunteer:FF=2ND force per unit area stabile value -1st force per unit area stabile valueGG=3th force per unit area stabile value – 1st force per unit area stabile valueAt T=40 grades C:HH=4th force per unit area stabile value -1st force per unit area stabile valueII=5th force per unit area stabile value -1st force per unit area stabile valueIt can be seen that neither the temperature nor the clip influence on the force per unit area. Now, averaging each vector obtained: FF -0.4930 GG -0.9040 HH -0.3840 Two -0.4660 Table Ten: mean values of force per unit area of all the stabile stairss for all the voluntaries in the unpumped stabile phase.Discussion2nd Part: Pressure CORRELATION BETWEEN CUFF AND PROBE ON LIMB PROTOTYPEQuestionThe chief job is that when we measure the air force per unit area in the force per unit area turnup, this force per unit area has been assumed to correlate to the force per unit area applied by the investigation to the tegument. However, this is an indirect measuring that has ne'er been decently evaluated until now. To give an illustration of how unsure is the premise of correlativity between the force per unit area in the turnup and the force per unit area applied by the investigation to the tegument: if the force per unit area turnup is attached really tight on top of the investigation, the turnup will definitively do a force per unit area onto the investigation and accordingly, onto the tegument ; however, the air force per unit area will demo still 0mmHg. To get down with a simple mark, this correlativity is to be tested on limb paradigms, different diameters of tubings folded with different breadths and hardness of froths. Furthermore, there are several constructs unknown: the optimum size of the investigation, the optimum arrangement of the turnup and the investigation, the optimum testing tissue and the optimum methodological analysis of acquiring consequences. In this portion we the investigation size, the investigation and turnup arrangement and the â€Å" tissue † ( represented by a froth hardness and breadth ) are tested.SET-UPPF 472 digital/analog convertorA convertor from linear signal to digital signal, to change over the signal from the force per unit area detector into digital signal sent to Perimed PSW 2,5 package.PF 5000 Doppler proctor which includestwo PF 5010 Laser Doppler Perfusion Monitoring ( LDPM ) unitsThe PF 5010 LDPM Unit is used for blood perfusion measurings based on optical maser Doppler engineering. Laser Doppler measures the sum, local microvascular flow including capillaries, arteriolas, venulas and shunts. Each unit includes one optical maser Doppler investigation.P F 5020 Temperature unitThe PF 5020 Temperature Unit is used toA execute local heat aggravation and/or temperature measurings. The PF 5020 unit has two connections for either thermostatic optical maser Doppler probes and/or temperature measuring detectors.one ( Numberss or letters ) PF 5050 Pressure UnitThe PF 5050 Pressure Unit is used to command additive or instant turnup force per unit area deflation. It has been developed to simplify and standardise trials such as Skin Perfusion Pressure ( SPP ) .Computer with Perimed PSW 2,5 packagePSW 2,5 package will let to obtain the measurings of the PF 5000 Doppler proctor numerically.8 A201 FlexiForce force detectorsSensitive force detectors are needed in order to correlate the mechanical force per unit area of the turnup and of the investigation.SC10 and SC20 Hokanson force per unit area turnups ( 10 centimeter and 12 centimeter )A force per unit area turnup is a device that shows the force per unit area in mmHg inside the cuff chamber. T he breadth required will depend on the breadth of the mark to be measured. The turnup should be 20 % wider than the mark. In our instance, the mark is the in-between calf. hypertext transfer protocol: //www.deh-inc.com/userfiles/image/SC12D % 20PP.jpgUPC2.5 Hokanson force per unit area turnup ( 2.5 centimeter )A force per unit area turnup of 2.5 centimeter of breadth, which will needed for the smallest tubing ( Xcm diameter ) .Pressure pump WelchAllyn 2005A force per unit area pump will pump air into the force per unit area turnup.Two 457 ( 357 ) Angled Small Thermostatic Laser Doppler ProbeProbe 457 is a combined optical maser Doppler and thermostatic investigation used for local heat aggravation while blood perfusion is measured. Its optical fibers are integrated in the het country and therefore the whole tissue country under the investigation will be heated. Its fibre separation is 0.25 millimeter. investigation 457457 Probe SupportA support is required in order to enlarge the country of the investigation therefore avoiding leaning and increasing contact with the investigation. ( our sentiment until the following experimentsssssssss ) ? ?457 Probe Support ( lined-up )A support is required in order to enlarge the country of the investigation therefore avoiding leaning and increasing contact with the investigation. ( our sentiment until the following experimentsssssssss ) . Since it was tested that the bottom portion of the support was 0.5mm deeper in tallness than the investigation, a lining-up has been realized in order to prove the consequence of this difference on the consequences.Probe 457 Silicone SupportA more flexible support than the Probe 457 Support will be tested.PF 105-3 double-sided adhesive stripsStrips are used for arrested development of the tegument and the investigationTen, 5cm and 10.5 centimeter diameter tubingsHard plastic tubings that are used as a limb par adigm.1mm, 5mm, 2cm soft froth and 1.5cm, 2.5cm difficult frothThe thickness and hardness of the different froths will play the tissue function around the tubings. Robin goodfellows, peacesaˆÂ ¦ . PHOTO Limb paradigm, tubing of 10cm of diameter ) PhotographMethodConditioning and standardization of the detectorThe detector Flexiforce is constructed of two beds of substrate composed of polyester movie. On each bed a conductive stuff ( Ag ) is applied, followed by a bed of pressure-sensitive ink. When force applied the electric resistance of Ag diminishes ( the conductance additions ) . Since the electric resistance is reciprocally relative to coerce, the force value can be obtained. After having the detectors the first measure to develop was to mount the electronic box, aid from one expert in electronics was needed from Perimed. The first measure before get downing the measurings is to condition the detector every bit good as understanding how it works. Unfortunately it has been clip demanding to carry through both stages. Here it is the detector ‘s electronic box set-up, where the V entire power has been changed from -1 V to -0.165 V to avoid impregnation of the electromotive force, hence, higher force end product values where obtained. Figure ten: recommended and innitial circuit of the Flexiforce detector. After the first group of measurings, the V T power has been changed from -1V to -0.165 V to avoid impregnation. About the conditioning, the User Manual have been followed exhaustively. The undermentioned stairss have been required to condition the detector: Design of 2 Pucks, little force concentrators and one for each side of the feeling country, to guarantee that all the force travels through the sensing country. It was necessary since the contact country of the burden was excessively big for the sensing country, which has 9.53 millimeter of diameter, see figure X. Perimed manufactured the Pucks. Double-side spines were used to repair the feeling country with the Pucks. Figure ten: Flexiforce sensor A-201. It has a thickness of 0.208mm, length of 197mm and feeling country of 9.53 millimeters diameter. It was recommended to put 110 % ( or more ) of the maximal trial burden onto the detector for about 3 seconds, reiterating in the process 5 times. However, since the highest trial burden was unknown at the beginning, the first 5 detectors have non been conditioned decently. The initial burden trial to status was around 50 N. The remainder of the detectors have been conditioned at around 70 N. Once the detector is conditioned, a standardization is required. In order to make that two stairss were required. It was suggested to put 1/3, 2/3 and the full trial weight on the detector, and mensurating during the timeframe to be used during the existent measurings. Since the full trial weight was still unknown at the beginning, 4 different weights ( 50g, 110g, 300g and 700g ) were used in order to obtain the additive relation between the input value and the end product value. The timeframe was considered to be 30 sec. It was tough to happen quotable consequences. Once the additive arrested development was found, the values were calibrated in the plan sing the weight of the objects, so the existent theoretical force of the objects used to be weighted.Initial jobs of the detectorUsing 110g weight objects it was troublesome to acquire quotable measurings. Then, farther double-side spines started to be used between the Pucks and the upper and lower objects. Furthermore, the consequences turned to be more quotable when the weight was situated precisely at the same topographic point in every measuring thanks to two perpendicular walls that supported a horizontal card, that contained boundaries that fitted with the cylinder form of the weight. Unfortunately the detector was found to be excessively sensitive, any somewhat weight difference in lading along the lading country brought different consequences. Linearity ( Error ) +/- 3 % Repeatability +/- 2.5 % of full graduated table ( conditioned detector, 80 % force applied ) Hysteresis & lt ; 4.5 % of full graduated table ( conditioned detector, 80 % force applied ) Drift & lt ; 5 % per logarithmic clip graduated table ( changeless burden of 90 % detector evaluation ) Response Time & lt ; 5 microseconds Output Change/Degree F Up to 0.2 % ( ~0.36 % / A °C ) . Loads & lt ; 10 pound, runing temperature can be increased to 165A °F ( 74A °C ) . Table ten: different detector belongingss. From the tabular array X it can be seen that the force detector has several issues that could take to non-valid consequences. The one-dimensionality mistake is thought to be overcome it by mensurating many times the same value. The hysteresis is checked by utilizing two weights ( 100g, 300g ) and mensurating while puting the first one, puting the 2nd one, and taking and puting the 2nd object while maintaining the first. No farther surveies were done about impetus. Response clip was measured thanks to a force per unit area turnup and it was established to be around 1 sec. Finally, about temperature influence, the room has been kept all the clip between 23 and 25 grades Celsius.The first measuringsInitially 4 parametric quantities have been studied: breadth of the low contact country of the support with the limb, tallness of the support, surface country of the upper contact country of the support with the force per unit area turnup and hardness of the surface of the limb. Alternatively of a human limb, a cylinder of 10cm of diameter and 60cm long has been used with two different hardness froths in each terminal, difficult ( white ) and soft ( Grey ) , figure ten. ( exposure ) . The first measurings were performed with the detector on the surface of the limb, below the investigation support and on top, the turnup environing the limb, see figure X. However, the Pucks moved from the halfway portion of the detector country, the tortuosity and non-vertical forces from the turnup moved the support. So there was low repeatability of the first measurings owing to both high sensitiveness and the instability of the base of the support on top of the limb. The first chief job to work out was instability, the detector was situated on top of the support alternatively, so higher surface was being stack on the limb. On top of the detector a stabilising piece was designed, figure X, in order to avoid non-vertical forces from the force per unit area turnup. Furthermore, tape was carefully set to repair all the objects on top of the protolimb. Consequently the repeatability increased well and since all the interior set-up was more stable, the high sensitiveness was non a job. In order to analyze the parametric quantities different pieces were designed, the farther manufacturation was carried by Perimed. In the tabular array below X all the different pieces are list.WIDTH & A ; HEIGHT ( short cylinders )UPPER CONTACT AREA ( semicylinders )Hardness4cm diameter * 1.5cm tallness 10.3cm radius. 1cm height * 11.3cm lenght 1.3cm midst froth 4cm diameter * 0.85cm tallness 4cm radius. 1cm height * 15cm lenght 0.3cm midst froth 5cm diameter * 1.5cm tallness 4cm radius. 1cm height * 3.2cm lenght 5cm diameter * 0.85cm tallness 2.5cm diameter * 1.5cm tallness 2.5cm diameter * 0.85cm tallness Table Ten: all the pieces designed for farther trials. Since the detector is truly sensitive to temperature and fragile ( it brakes if the feeling country is somewhat folded ) a weight of 110g is used to look into if it is decently calibrated and if it works before each measuring. It is to be mentioned that the spines to repair all the objects on top of each other, and specially for repairing the Pucks on the feeling country brought two chief effects: the advantageous effect is that the objects moved from each other when there were high tortuosity or horizontal forces, which meant that the set-up with the force per unit area turnup had to be improved, merely perpendicular forces were aimed. The drawback is that because of the moving of the objects, the spines moved and they had to be replaced, which lead to 5 broken detectors. In order to pump the force per unit area cuff a manual force per unit area turnup was used at first half of the measurings until and automatic and more precise turnup was found in the company. That allowed to decrease the figure of perennial measurings. With the manual turnup, 20 measurings were considered to be necessary for each force per unit area value from the force per unit area turnup: 100mmHg, 75mmHg and 50mmHg in the bulk of the instances. The procedure got less boring and faster when utilizing the automatic force per unit area turnup, so, merely 4 measurings were carried for each value. The 100mmHg value was ever the get downing value, since it is a considerable high force per unit area the interior set-up can be moved. By get downing with this value we avoid mensurating the 40 other values ( 20 per 50mmHg and 20 per 75mmHg ) in vain. The 2nd job found on the manner of the measurings was that with the electronic circuit the values got saturated at 20mmHg. Therefore the V entire end product was changed from -1 V to -0.156 V to acquire lower electric resistance by the detector, in other words, to acquire higher values of force. Now the impregnation degre